Clarence is a town and affluent suburb located in the northeastern part of Erie County, New York, United States, northeast of Buffalo. The population was 32,950 according to the 2020 census estimate. This represents an increase of 7.4% from the 2010 census figure. The Clarence census-designated place occupies the southeast part of the town and roughly corresponds to a postal district with ZIP code 14031 and 14221 in the western side which it shares with nearby Williamsville. The town is named in honor of Prince William, Duke of Clarence and St Andrews (1765–1837), the third son of King George III and later king himself, as William IV.

Erie County is a county along the shore of Lake Erie in western New York State. As of the 2020 census, the population was 954,236. The county seat is Buffalo, which makes up about 28% of the county's population. Both the county and Lake Erie were named for the regional Iroquoian language-speaking Erie tribe of Native Americans, who lived in the area before 1654. They were later pushed out by the more powerful Iroquoian nations tribes. The county is part of the Western New York region of the state.