Clarice Orsini (1453–1488) was the daughter of Jacopo Orsini, and his wife and cousin Maddalena Orsini both from the Orsini family, a great Roman noble house and was the wife of Lorenzo de' Medici.

The House of Orsini is an Italian noble family that was one of the most influential princely families in medieval Italy and Renaissance Rome. Members of the Orsini family include five popes: Stephen II (752–757), Paul I (757–767), Celestine III (1191–1198), Nicholas III (1277–1280), and Benedict XIII (1724–1730). The family also included 34 cardinals, numerous condottieri, and other significant political and religious figures.