Lorenzo di Piero de' Medici, known as Lorenzo the Magnificent, was an Italian statesman, the de facto ruler of the Florentine Republic, and the most powerful patron of Renaissance culture in Italy. Lorenzo held the balance of power within the Italic League, an alliance of states that stabilized political conditions on the Italian Peninsula for decades, and his life coincided with the mature phase of the Italian Renaissance and the golden age of Florence. As a patron, he is best known for his sponsorship of artists such as Botticelli and Michelangelo. On the foreign policy front, Lorenzo manifested a clear plan to stem the territorial ambitions of Pope Sixtus IV, in the name of the balance of the Italic League of 1454. For these reasons, Lorenzo was the subject of the Pazzi conspiracy (1478), in which his brother Giuliano was assassinated. The Peace of Lodi of 1454 that he supported among the various Italian states collapsed with his death. He is buried in the Medici Chapel in Florence.

Cosimo di Giovanni de' Medici was an Italian banker and politician who established the Medici family as effective rulers of Florence during much of the Italian Renaissance. His power derived from his wealth as a banker and intermarriage with other rich and powerful families. He was a patron of arts, learning, and architecture. He spent over 600,000 gold florins on art and culture, including Donatello's David, the first freestanding nude male sculpture since antiquity.