Lorenzo di Piero de' Medici, known as Lorenzo the Magnificent, was an Italian statesman, the de facto ruler of the Florentine Republic, and the most powerful patron of Renaissance culture in Italy. Lorenzo held the balance of power within the Italic League, an alliance of states that stabilized political conditions on the Italian Peninsula for decades, and his life coincided with the mature phase of the Italian Renaissance and the golden age of Florence. As a patron, he is best known for his sponsorship of artists such as Botticelli and Michelangelo. On the foreign policy front, Lorenzo manifested a clear plan to stem the territorial ambitions of Pope Sixtus IV, in the name of the balance of the Italic League of 1454. For these reasons, Lorenzo was the subject of the Pazzi conspiracy (1478), in which his brother Giuliano was assassinated. The Peace of Lodi of 1454 that he supported among the various Italian states collapsed with his death. He is buried in the Medici Chapel in Florence.

The Republic of Florence, known officially as the Florentine Republic, was a medieval and early modern state that was centered on the Italian city of Florence in Tuscany, Italy. The republic originated in 1115, when the Florentine people rebelled against the Margraviate of Tuscany upon the death of Matilda of Tuscany, who controlled vast territories that included Florence. The Florentines formed a commune in her successors' place. The republic was ruled by a council known as the Signoria of Florence. The signoria was chosen by the gonfaloniere, who was elected every two months by Florentine guild members.