Coele-Syria was a region of Syria in classical antiquity. The term originally referred to the "hollow" Beqaa Valley between the Lebanon and the Anti-Lebanon mountain ranges, but sometimes it was applied to a broader area of the region of Syria. The area is now part of modern-day Syria and Lebanon.

The Syrian Wars were a series of six wars between the Seleucid Empire and the Ptolemaic Kingdom of Egypt, successor states to Alexander the Great's empire, during the 3rd and 2nd centuries BC over the region then called Coele-Syria, one of the few avenues into Egypt. These conflicts drained the material and manpower of both parties and led to their eventual destruction and conquest by Rome and Parthia. They are briefly mentioned in the biblical Books of the Maccabees.