The Syrian Wars were a series of six wars between the Seleucid Empire and the Ptolemaic Kingdom of Egypt, successor states to Alexander the Great's empire, during the 3rd and 2nd centuries BC over the region then called Coele-Syria, one of the few avenues into Egypt. These conflicts drained the material and manpower of both parties and led to their eventual destruction and conquest by Rome and Parthia. They are briefly mentioned in the biblical Books of the Maccabees.

Seleucus II Callinicus Pogon, was a ruler of the Hellenistic Seleucid Empire, who reigned from 246 BC to 225 BC. Faced with multiple enemies on various fronts, and not always successful militarily, his reign was a time of great turmoil and fragmentation for the Seleucid empire, before its eventual restoration under his second son and eventual successor, Antiochus III.