Colona is a city in Henry County, Illinois, along the Green River. It is part of the Quad Cities metropolitan area. The population was 5,307 at the 2020 census, up from 5,099 at the 2010 census.

Henry County is a county located in the U.S. state of Illinois. The 2020 United States Census, listed its population at 49,284. Its county seat is Cambridge.