The Compañía General de Tabacos de Filipinas, S.A., also known as the Compañía Española de Tabacos de Filipinas, was a Spanish multinational joint-stock company, one of the world's most important enterprises in the late 19th and early 20th century, and the Philippines' first private tobacco company. Founded by the 1st Marquess of Comillas in Barcelona in 1881 and based in Manila, it is also simply known as Tabacos de Filipinas in Spain, and as La Tabacalera in the Philippines.

Antonio López y López, 1st Marquess of Comillas, GE, was a Spanish businessman, slave trader and shipping magnate. He was the founder of a number of important companies, and one of the wealthiest men in the second half of the 19th century.