The Deskpro 386 is a line of desktop computers in Compaq's Deskpro range of IBM PC compatibles. The computers feature Intel's 32-bit 80386 microprocessor. Introduced in September 1986, the Deskpro 386 was the first personal computer to feature an 80386 processor. It also marks the first time that a major component of the IBM Personal Computer de facto standard was updated by a company other than IBM themselves—in this case, upgrading from the 80286 processor of the Personal Computer/AT.

Compaq Computer Corporation was an American information technology company founded in 1982 that developed, sold, and supported computers and related products and services. Compaq produced some of the first IBM PC compatible computers, being the second company after Columbia Data Products to legally reverse engineer the BIOS of the IBM Personal Computer. It rose to become the largest supplier of PC systems during the 1990s before being overtaken by Dell in 2001. Struggling to keep up in the price wars against Dell, as well as with a risky acquisition of DEC, Compaq was acquired for US$25 billion by HP in 2002. The Compaq brand remained in use by HP for lower-end systems until 2013 when it was discontinued. Since 2013, the brand is currently licensed to third parties for use on electronics in Brazil and India.