Constantine Samuel Rafinesque-Schmaltz was a French early 19th-century polymath born near Constantinople in the Ottoman Empire and self-educated in France. He traveled as a young man in the United States, ultimately settling in Ohio in 1815, where he made notable contributions to botany, zoology, and the study of prehistoric earthworks in North America. He also contributed to the study of ancient Mesoamerican linguistics, in addition to work he had already completed in Europe.

Many pre-Columbian cultures in North America were collectively termed "Mound Builders", but the term has no formal meaning. It does not refer to specific people or archaeological culture but refers to the characteristic mound earthworks that indigenous peoples erected for an extended period of more than 5,000 years. The "Mound Builder" cultures span the period of roughly 3500 BCE to the 16th century CE, including the Archaic period, Woodland period, and Mississippian period. Geographically, the cultures were present in the region of the Great Lakes, the Ohio River Valley, Florida, and the Mississippi River Valley and its tributary waters.