The Constellation program was a crewed spaceflight program developed by NASA, the space agency of the United States, from 2005 to 2009. The major goals of the program were "completion of the International Space Station" and a "return to the Moon no later than 2020" with a crewed flight to the planet Mars as the ultimate goal. The program's logo reflected the three stages of the program: the Earth (ISS), the Moon, and finally Mars—while the Mars goal also found expression in the name given to the program's booster rockets: Ares. The technological aims of the program included the regaining of significant astronaut experience beyond low Earth orbit and the development of technologies necessary to enable sustained human presence on other planetary bodies.

Human spaceflight is spaceflight with a crew or passengers aboard a spacecraft, often with the spacecraft being operated directly by the onboard human crew. Spacecraft can also be remotely operated from ground stations on Earth, or autonomously, without any direct human involvement. People trained for spaceflight are called astronauts, cosmonauts (Russian), or taikonauts (Chinese); and non-professionals are referred to as spaceflight participants or spacefarers.