Cooper Square is a junction of streets in Lower Manhattan in New York City located at the confluence of the neighborhoods of Bowery to the south, NoHo to the west and southwest, Greenwich Village to the west and northwest, the East Village to the north and east, and the Lower East Side to the southeast.

Third Avenue is a north-south thoroughfare on the East Side of the New York City borough of Manhattan, as well as in the center portion of the Bronx. Its southern end is at Astor Place and St. Mark's Place. It transitions into Cooper Square, and further south, the Bowery, Chatham Square, and Park Row. The Manhattan side ends at East 128th Street. Third Avenue is two-way from Cooper Square to 24th Street, but carries only northbound (uptown) traffic while in Manhattan above 24th Street; in the Bronx, it is again two-way. However, the Third Avenue Bridge carries vehicular traffic in the opposite direction, allowing only southbound vehicular traffic, rendering the avenue essentially non-continuous to motor vehicles between the boroughs.