County Route 66 is an east–west numbered road in San Bernardino County, California, United States. It runs for 175.7 miles (282.8 km) from Oro Grande to the U.S. Route 95 (US 95) at Arrowhead Junction. The entire route is part of the former U.S. Route 66 (US 66), connecting towns that were bypassed by Interstate 40 (I-40) such as Oro Grande and Amboy. It is the only numbered county route in San Bernardino County.

U.S. Route 95 (US 95) is a United States Numbered Highway, stretching from the Mexican border in San Luis, Arizona to the Canadian border near Eastport, Idaho. The California portion of US 95 traverses through the far eastern edges of both Riverside and San Bernardino counties. US 95 serves Blythe and Needles and junctions with SR 62 at Vidal Junction.