The Cradle of Humankind is a paleoanthropological site and is located about 50 km (31 mi) northwest of Johannesburg, South Africa, in the Gauteng province. Declared a World Heritage Site by UNESCO in 1999, the site is home to the largest concentration of human ancestral remains anywhere in the world. The site currently occupies 47,000 hectares (180 sq mi) and contains a complex system of limestone caves. The registered name of the site in the list of World Heritage Sites is Fossil Hominid Sites of South Africa.

Johannesburg is the most populous city in South Africa with 4,803,262 people, and is classified as a megacity; it is one of the 100 largest urban areas in the world. It is the provincial capital and largest city of Gauteng, which is the wealthiest province in South Africa. Johannesburg is the seat of the Constitutional Court, the highest court in South Africa. Most of the major South African companies and banks have their head offices in Johannesburg. The city is located within the mineral-rich Witwatersrand hills, the epicentre of the international-scale mineral, gold and (specifically) diamond trade.