The Craighead–Jackson House is a historic two-story, brick house in Knoxville, in the U.S. state of Tennessee. The home was constructed by John Craighead in 1818 across the street from the William Blount Mansion. The house is on the National Register of Historic Places.

The Blount Mansion, also known as William Blount Mansion, located at 200 West Hill Avenue in downtown Knoxville, Tennessee, was the home of the only territorial governor of the Southwest Territory, William Blount (1749–1800). Blount, a Founding Father of the United States, a signer of the United States Constitution, and a U.S. Senator from Tennessee, lived on the property with his family and ten African-American slaves. The mansion served as the de facto capitol of the Southwest Territory. In 1796, much of the Tennessee Constitution was drafted in Governor Blount's office at the mansion. Tennessee state historian John Trotwood Moore once called Blount Mansion "the most important historical spot in Tennessee."