Dr. Dana Katherine Scully, MD, is a fictional character and one of the two protagonists in the Fox science-fiction, supernatural television series The X-Files, played by Gillian Anderson. Scully is a Federal Bureau of Investigation (FBI) Special Agent and a medical doctor (MD), partnered with fellow Special Agent Fox Mulder for seasons one to seven and seasons 10 and 11, and with John Doggett in the eighth and ninth seasons. In the television series, they work out of a cramped basement office at FBI headquarters in Washington, DC to investigate unsolved cases labeled "X-Files." In 2002, Scully left government employment, and in 2008, she began working as a surgeon in Our Lady of Sorrows, a private Catholic hospital – where she stayed for seven years, until rejoining the FBI. In contrast to Mulder's credulous "believer" character, Scully is the skeptic for the first seven seasons, choosing to base her beliefs on what science can prove. She later on becomes a "believer" after Mulder's abduction at the end of season seven.

The X-Files is a 1998 American science fiction thriller film based on Chris Carter's television series of the same name, which revolves around fictional unsolved cases called the X-Files and the characters solving them. It was directed by Rob Bowman, written by Carter and Frank Spotnitz and featured five main characters from the television series: David Duchovny, Gillian Anderson, Mitch Pileggi, John Neville, and William B. Davis reprise their respective roles as FBI agents Fox Mulder and Dana Scully, FBI Assistant Director Walter Skinner, Well-Manicured Man, and the Cigarette-Smoking Man. The film was promoted with the tagline Fight the Future.