The DeSoto Series S-10 is an automobile produced by DeSoto from 1942 through to the 1952 model year. While in production, the Series S-10, which was sold with the trim package DeLuxe, was DeSoto's entry-level car, and was offered primarily as two-door and four-door sedans while the Custom offered upscale interiors and appearance including a 7-passenger sedan and the extended-wheelbase Suburban sedans. The body was claimed to be "rust proofed".

DeSoto was an American automobile marque that was manufactured and marketed by the DeSoto division of Chrysler Corporation from 1928 to the 1961 model year. More than two million passenger cars and trucks bore the DeSoto brand in North American markets during its existence.