De Leon is a city located in Comanche County in the U.S. state of Texas. Its population was 2,246 in the 2020 census. It is commonly associated with being named after the Spanish explorer Ponce de León, but the town is actually named for its location on the Leon River, which flows directly north and east of the community, and drains into nearby Proctor Lake.

Comanche County is a county located on the Edwards Plateau in Central Texas. As of the 2020 census, its population was 13,594. The county seat is Comanche. The county was founded in 1856 and is named for the Comanche Native American tribe.