The Death Valley pupfish, also known as Salt Creek pupfish, is a small species of fish in the family Cyprinodontidae found only in Death Valley National Park, California, United States. There are two recognized subspecies: C. s. salinus and C. s. milleri. The Death Valley pupfish is endemic to two small, isolated locations and currently classified as endangered.

Death Valley National Park is an American national park that straddles the California–Nevada border, east of the Sierra Nevada. The park boundaries include Death Valley, the northern section of Panamint Valley, the southern section of Eureka Valley and most of Saline Valley.