Dedication 2 is the sixth mixtape by Lil Wayne, hosted by DJ Drama. It is a sequel to Lil Wayne's previous mixtape, The Dedication, and is second in DJ Drama's Gangsta Grillz series with Lil Wayne. It is one of the few mixtapes in the hip hop genre to be both financially successful and critically acclaimed. Despite its illegal use of unlicensed instrumentals and samples, it was sold through iTunes and retail stores such as Best Buy and FYE, was widely reviewed in the mainstream media, and peaked at #69 on Billboard's "Top R&B/Hip-Hop Albums” chart. The cover shows Lil Wayne with "Fear God" tattooed on his eyelids. Much of the mixtape showcases Lil Wayne's free associating rhymes and "liquid non-sequiturs."

Tyree Cinque Simmons, known professionally as DJ Drama, is an American disc jockey (DJ), record executive and music promoter. He initially gained recognition as the DJ for Atlanta-based rapper T.I., and continued to gain prominence hosting mixtapes for other hip hop artists. His trademark Gangsta Grillz series is present on releases of which he has compiled; it has been popularized by artists including Lil Wayne, Tyler the Creator, Snoop Dogg, Yo Gotti, YoungBoy Never Broke Again, Fabolous, Jeezy, Meek Mill, and Gucci Mane, among others. Alongside record producer and fellow Philadelphia native Don Cannon, he co-founded the record label Generation Now in 2015, an imprint of Atlantic Records which has signed artists including Lil Uzi Vert and Jack Harlow.