Deep Blue Sea is a 1999 American science fiction horror film directed by Renny Harlin and starring Saffron Burrows, Thomas Jane, Samuel L. Jackson, Michael Rapaport, and LL Cool J. It is the first film of the film series by the same name. Set in an isolated underwater facility, the film follows a team of scientists and their research on mako sharks to help fight Alzheimer's disease. The situation plunges into chaos when multiple genetically engineered sharks go on a rampage and flood the facility.