Delancey Street is one of the main thoroughfares of New York City's Lower East Side in Manhattan, running from the street's western terminus at the Bowery to its eastern end at FDR Drive, connecting to the Williamsburg Bridge and Brooklyn at Clinton Street. It is an eight-lane, median-divided street west of Clinton Street, and a service road for the Williamsburg Bridge east of Clinton Street. West of Bowery, Delancey Street becomes Kenmare Street, which continues as a four-lane, undivided street to Lafayette Street.

The Lower East Side, sometimes abbreviated as LES, is a historic neighborhood in the southeastern part of Manhattan in New York City. It is located roughly between the Bowery and the East River from Canal to Houston streets. Historically, it was understood to encompass a much larger area, from Broadway to the East River and from East 14th Street to Fulton and Franklin Streets.