Demerara-Mahaica is a region of Guyana, bordering the Atlantic Ocean to the north, the region of Mahaica-Berbice to the east, the region of Upper Demerara-Berbice to the south and the region of Essequibo Islands-West Demerara to the west.

Essequibo Islands-West Demerara is a region of Guyana. It is situated around the Essequibo River, the largest river in Guyana that lies between the Orinoco and Amazon rivers of South America.