The Destruction of Neuss occurred in July 1586, during the Cologne War. Alexander Farnese, Duke of Parma's troops surrounded the city of Neuss, an important Protestant garrison in the Electorate of Cologne. After the city refused to capitulate, Parma's army reduced the city to rubble through a combination of artillery fire, destructive house-to-house fighting, and plundering; during the battle, a fire started that destroyed most of the rest of the city. Approximately 3,000 civilians died, out of a population of around 4,500, and the entire garrison was killed.

Alexander Farnese was an Italian noble and condottiero, and a general of the Spanish army, who was Duke of Parma, Piacenza and Castro from 1586 to 1592, as well as Governor of the Spanish Netherlands from 1578 to 1592. Thanks to a steady influx of troops from Spain, during 1581–1587 Farnese captured more than thirty towns in the south and returned them to the control of Habsburg Spain. During the French Wars of Religion he relieved Paris for the Catholic League. His talents as a commander on the battlefield, strategist and organizer earned him the regard of his contemporaries and military historians as the first captain of his age.