Dioxins and dioxin-like compounds are a group of chemical compounds that are persistent organic pollutants in the environment. They are mostly by-products of burning or various industrial processes or
A schematic diagram of some AHR signaling pathways. The canonical pathway is depicted with solid black arrows, alternative pathways with dashed arrows, and an intersection of these two with a solid red arrow. The green bars represent the AHR, red bars ARNT, yellow bars ARA9 (AIP, Xap2), blue bars HSP90, and the blue ovals p23. Dioxin binding to the AHR (1.) leads to its translocation into the nucleus by importin-β, (2.) heterodimerization with ARNT and binding to the DNA at DREs, (3.) modulating expression levels of target genes (green arrows). One of the gene products elevated by this mechanism is AHRR, a
Decrease of dioxin concentrations in breast milk in Sweden and Finland
Decrease of dioxins in ambient air in different regions (redrawn from Dopico and Gomez, 2015)
Polychlorinated dibenzodioxins, or simply dioxins, are a group of long-lived polyhalogenated organic compounds that are primarily anthropogenic, and contribute toxic, persistent organic pollution in t
Dioxins and dioxin-like compounds
…hydrocarbon receptor (AH receptor), albeit with very different binding affinities, leading to high differences in toxicity and other effects. They include: Polychlorinated dibenzo-p-dioxins (PCDDs), often referred to simply as dioxins. PCDDs are derivatives of dibenzo-p-dioxin. There are 75 PCDD congeners, differing in the number and…
U.S. Army Huey helicopter spraying Agent Orange over Vietnamese agricultural land
Spolana Neratovice chloralkali plant, air view
Viktor Yushchenko with chloracne after his TCDD poisoning incident