A disease is a particular abnormal condition that negatively affects the structure or function of part or all of an organism, and that is not due to any external injury. Diseases are often construed as medical conditions that are associated with specific symptoms and signs. A disease may be caused by external factors such as pathogens or by internal dysfunctions. For example, internal dysfunctions of the immune system can produce a variety of different diseases, including various forms of immunodeficiency, hypersensitivity, allergies and autoimmune disorders.
In humans, disease is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person afflicted, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories. Diseases can affect people not only physically, but also emotionally, as contracting and living with a disease can alter the affected person's perspective on life.
Death due to disease is called death by natural causes. There are four main types of disease: infectious diseases, deficiency diseases, hereditary diseases (including both genetic diseases and non-genetic hereditary diseases), and physiological diseases. Diseases can also be classified in other ways, such as communicable versus non-communicable diseases. The deadliest diseases in humans are coronary artery disease (blood flow obstruction), followed by cerebrovascular disease and lower respiratory infections.
In many cases, terms such as disease, disorder, morbidity, sickness and illness are used interchangeably. There are situations, however, when specific terms are considered preferable.
- The term disease broadly refers to any condition that impairs the normal functioning of the body. For this reason, diseases are associated with dysfunctioning of the body's normal homeostatic processes. Commonly, the term is used to refer specifically to infectious diseases, which are clinically evident diseases that result from the presence of pathogenic microbial agents, including viruses, bacteria, fungi, protozoa, multicellular organisms, and aberrant proteins known as prions. An infection or colonization that does not and will not produce clinically evident impairment of normal functioning, such as the presence of the normal bacteria and yeasts in the gut, or of a passenger virus, is not considered a disease. By contrast, an infection that is asymptomatic during its incubation period, but expected to produce symptoms later, is usually considered a disease. Non-infectious diseases are all other diseases, including most forms of cancer, heart disease, and genetic disease.
- Acquired disease
- An acquired disease is one that began at some point during one's lifetime, as opposed to disease that was already present at birth, which is congenital disease. Acquired sounds like it could mean "caught via contagion", but it simply means acquired sometime after birth. It also sounds like it could imply secondary disease, but acquired disease can be primary disease.
- Acute disease
- An acute disease is one of a short-term nature (acute); the term sometimes also connotes a fulminant nature
- Chronic condition or chronic disease
- A chronic disease is one that persists over time, often characterized six months or more.
- Congenital disorder or congenital disease
- A congenital disorder is one that is present at birth. It is often a genetic disease or disorder and can be inherited. It can also be the result of a vertically transmitted infection from the mother, such as HIV/AIDS.
- Genetic disease
- A genetic disorder or disease is caused by one or more genetic mutations. It is often inherited, but some mutations are random and de novo.
- Hereditary or inherited disease
- A hereditary disease is a type of genetic disease caused by genetic mutations that are hereditary (and can run in families)
- Iatrogenic disease
- An iatrogenic disease or condition is one that caused by medical intervention, whether as a side effect of a treatment or as an inadvertent outcome.
- Idiopathic disease
- An idiopathic disease has an unknown cause or source. As medical science has advanced, many diseases with entirely unknown causes have had some aspects of their sources explained and therefore shed their idiopathic status. For example, when germs were discovered, it became known that they were a cause of infection, but particular germs and diseases had not been linked. In another example, it is known that autoimmunity is the cause of some forms of diabetes mellitus type 1, even though the particular molecular pathways by which it works are not yet understood. It is also common to know certain factors are associated with certain diseases. However, association and causality are two very different phenomena, as a third cause might be producing the disease, as well as an associated phenomenon.
- Incurable disease
- A disease that cannot be cured. Incurable diseases are not necessarily terminal diseases, and sometimes a disease's symptoms can be treated sufficiently for the disease to have little or no impact on quality of life.
- Primary disease
- A primary disease is a disease that is due to a root cause of illness, as opposed to secondary disease, which is a sequela, or complication that is caused by the primary disease. For example, a common cold is a primary disease, where rhinitis is a possible secondary disease, or sequela. A doctor must determine what primary disease, a cold or a bacterial infection, is causing a patient's secondary rhinitis when deciding whether or not to prescribe antibiotics.
- Secondary disease
- A secondary disease is a disease that is a sequela or complication of a prior, causal disease, which is referred to as the primary disease or simply the underlying cause (root cause). For example, a bacterial infection can be primary, wherein a healthy person is exposed to a bacteria and becomes infected, or it can be secondary to a primary cause, that predisposes the body to infection. For example, a primary viral infection that weakens the immune system could lead to a secondary bacterial infection. Similarly, a primary burn that creates an open wound could provide an entry point for bacteria, and lead to a secondary bacterial infection.
- Terminal disease
- A terminal disease is one that is expected to have the inevitable result of death. Previously, AIDS was a terminal disease; it is now incurable, but can be managed indefinitely using medications.
- The terms Illness and sickness are both generally used as a synonym for disease. However, the term illness is occasionally used to refer specifically to the patient's personal experience of his or her disease. In this model, it is possible for a person to have a disease without being ill (to have an objectively definable, but asymptomatic, medical condition, such as a subclinical infection), and to be ill without being diseased (such as when a person perceives a normal experience as a medical condition, or medicalizes a non-disease situation in his or her life—for example, a person who feels unwell as a result of embarrassment, and who interprets those feelings as sickness rather than normal emotions). Symptoms of illness are often not directly the result of infection, but a collection of evolved responses—sickness behavior by the body—that helps clear infection and promote recovery. Such aspects of illness can include lethargy, depression, loss of appetite, sleepiness, hyperalgesia, and inability to concentrate.
- A disorder is a functional abnormality or disturbance. Medical disorders can be categorized into mental disorders, physical disorders, genetic disorders, emotional and behavioral disorders, and functional disorders. The term disorder is often considered more value-neutral and less stigmatizing than the terms disease or illness, and therefore is a preferred terminology in some circumstances. In mental health, the term mental disorder is used as a way of acknowledging the complex interaction of biological, social, and psychological factors in psychiatric conditions. However, the term disorder is also used in many other areas of medicine, primarily to identify physical disorders that are not caused by infectious organisms, such as metabolic disorders.
- Medical condition
- A medical condition is a broad term that includes all diseases, lesions, disorders, or nonpathologic condition that normally receives medical treatment, such as pregnancy or childbirth. While the term medical condition generally includes mental illnesses, in some contexts the term is used specifically to denote any illness, injury, or disease except for mental illnesses. The Diagnostic and Statistical Manual of Mental Disorders (DSM), the widely used psychiatric manual that defines all mental disorders, uses the term general medical condition to refer to all diseases, illnesses, and injuries except for mental disorders. This usage is also commonly seen in the psychiatric literature. Some health insurance policies also define a medical condition as any illness, injury, or disease except for psychiatric illnesses.
- As it is more value-neutral than terms like disease, the term medical condition is sometimes preferred by people with health issues that they do not consider deleterious. On the other hand, by emphasizing the medical nature of the condition, this term is sometimes rejected, such as by proponents of the autism rights movement.
- The term medical condition is also a synonym for medical state, in which case it describes an individual patient's current state from a medical standpoint. This usage appears in statements that describe a patient as being in critical condition, for example.
- Morbidity (from Latin morbidus, meaning 'sick, unhealthy') is a diseased state, disability, or poor health due to any cause. The term may be used to refer to the existence of any form of disease, or to the degree that the health condition affects the patient. Among severely ill patients, the level of morbidity is often measured by ICU scoring systems. Comorbidity is the simultaneous presence of two or more medical conditions, such as schizophrenia and substance abuse.
- In epidemiology and actuarial science, the term "morbidity rate" can refer to either the incidence rate, or the prevalence of a disease or medical condition. This measure of sickness is contrasted with the mortality rate of a condition, which is the proportion of people dying during a given time interval. Morbidity rates are used in actuarial professions, such as health insurance, life insurance and long-term care insurance, to determine the correct premiums to charge to customers. Morbidity rates help insurers predict the likelihood that an insured will contract or develop any number of specified diseases.
- Pathosis or pathology
- Pathosis (plural pathoses) is synonymous with disease. The word pathology also has this sense, in which it is commonly used by physicians in the medical literature, although some editors prefer to reserve pathology to its other senses. Sometimes a slight connotative shade causes preference for pathology or pathosis implying "some [as yet poorly analyzed] pathophysiologic process" rather than disease implying "a specific disease entity as defined by diagnostic criteria being already met". This is hard to quantify denotatively, but it explains why cognitive synonymy is not invariable.
- A syndrome is the association of several medical signs, symptoms, or other characteristics that often occur together. Some syndromes, such as Down syndrome, have only one cause. Others, such as Parkinsonian syndrome, have multiple possible causes. For example, acute coronary syndrome is not a single disease itself, but rather the manifestation of any of several diseases, such as myocardial infarction secondary to coronary artery disease. In yet other syndromes, the cause is unknown. A familiar syndrome name often remains in use even after an underlying cause has been found, or when there are a number of different possible primary causes. Examples of the first-mentioned type are that Turner syndrome and DiGeorge syndrome are still often called by the "syndrome" name despite that they can also be viewed as disease entities and not solely as sets of signs and symptoms.
- Predisease is a subclinical or prodromal vanguard of a disease. Prediabetes and prehypertension are common examples. The nosology or epistemology of predisease is contentious, though, because there is seldom a bright line differentiating a legitimate concern for subclinical/prodromal/premonitory status (on one hand) and conflict of interest–driven disease mongering or medicalization (on the other hand). Identifying legitimate predisease can result in useful preventive measures, such as motivating the person to get a healthy amount of physical exercise, but labeling a healthy person with an unfounded notion of predisease can result in overtreatment, such as taking drugs that only help people with severe disease or paying for drug prescription instances whose benefit–cost ratio is minuscule (placing it in the waste category of CMS' "waste, fraud, and abuse" classification). One review summarizes 3 requirements for legitimacy of instances of the concept: truly high risk for progression to disease, actionability for risk reduction, and benefit that outweighs harm in any interventions taken.
Types by body system
- Mental illness is a broad, generic label for a category of illnesses that may include affective or emotional instability, behavioral dysregulation, cognitive dysfunction or impairment. Specific illnesses known as mental illnesses include major depression, generalized anxiety disorders, schizophrenia, and attention deficit hyperactivity disorder, to name a few. Mental illness can be of biological (e.g., anatomical, chemical, or genetic) or psychological (e.g., trauma or conflict) origin. It can impair the affected person's ability to work or study and can harm interpersonal relationships. The term insanity is used technically as a legal term.
- An organic disease is one caused by a physical or physiological change to some tissue or organ of the body. The term sometimes excludes infections. It is commonly used in contrast with mental disorders. It includes emotional and behavioral disorders if they are due to changes to the physical structures or functioning of the body, such as after a stroke or a traumatic brain injury, but not if they are due to psychosocial issues.
In an infectious disease, the incubation period is the time between infection and the appearance of symptoms. The latency period is the time between infection and the ability of the disease to spread to another person, which may precede, follow, or be simultaneous with the appearance of symptoms. Some viruses also exhibit a dormant phase, called viral latency, in which the virus hides in the body in an inactive state. For example, varicella zoster virus causes chickenpox in the acute phase; after recovery from chickenpox, the virus may remain dormant in nerve cells for many years, and later cause herpes zoster (shingles).
- Acute disease
- An acute disease is a short-lived disease, like the common cold.
- Chronic disease
- A chronic disease is one that lasts for a long time, usually at least six months. During that time, it may be constantly present, or it may go into remission and periodically relapse. A chronic disease may be stable (does not get any worse) or it may be progressive (gets worse over time). Some chronic diseases can be permanently cured. Most chronic diseases can be beneficially treated, even if they cannot be permanently cured.
- Clinical disease
- One that has clinical consequences; in other words, the stage of the disease that produces the characteristic signs and symptoms of that disease. AIDS is the clinical disease stage of HIV infection.
- A cure is the end of a medical condition or a treatment that is very likely to end it, while remission refers to the disappearance, possibly temporarily, of symptoms. Complete remission is the best possible outcome for incurable diseases.
- A flare-up can refer to either the recurrence of symptoms or an onset of more severe symptoms.
- Progressive disease
- Progressive disease is a disease whose typical natural course is the worsening of the disease until death, serious debility, or organ failure occurs. Slowly progressive diseases are also chronic diseases; many are also degenerative diseases. The opposite of progressive disease is stable disease or static disease: a medical condition that exists, but does not get better or worse.
- Refractory disease
- A refractory disease is a disease that resists treatment, especially an individual case that resists treatment more than is normal for the specific disease in question.
- Subclinical disease
- Also called silent disease, silent stage, or asymptomatic disease. This is a stage in some diseases before the symptoms are first noted.
- Terminal phase
- If a person will die soon from a disease, regardless of whether that disease typically causes death, then the stage between the earlier disease process and active dying is the terminal phase.
- Localized disease
- A localized disease is one that affects only one part of the body, such as athlete's foot or an eye infection.
- Disseminated disease
- A disseminated disease has spread to other parts; with cancer, this is usually called metastatic disease.
- Systemic disease
- A systemic disease is a disease that affects the entire body, such as influenza or high blood pressure.
Diseases may be classified by cause, pathogenesis (mechanism by which the disease is caused), or by symptom(s). Alternatively, diseases may be classified according to the organ system involved, though this is often complicated since many diseases affect more than one organ.
A chief difficulty in nosology is that diseases often cannot be defined and classified clearly, especially when cause or pathogenesis are unknown. Thus diagnostic terms often only reflect a symptom or set of symptoms (syndrome).
Classical classification of human disease derives from observational correlation between pathological analysis and clinical syndromes. Today it is preferred to classify them by their cause if it is known.
Only some diseases such as influenza are contagious and commonly believed infectious. The micro-organisms that cause these diseases are known as pathogens and include varieties of bacteria, viruses, protozoa and fungi. Infectious diseases can be transmitted, e.g. by hand-to-mouth contact with infectious material on surfaces, by bites of insects or other carriers of the disease, and from contaminated water or food (often via fecal contamination), etc. Also, there are sexually transmitted diseases. In some cases, microorganisms that are not readily spread from person to person play a role, while other diseases can be prevented or ameliorated with appropriate nutrition or other lifestyle changes.
Some diseases, such as most (but not all) forms of cancer, heart disease, and mental disorders, are non-infectious diseases. Many non-infectious diseases have a partly or completely genetic basis (see genetic disorder) and may thus be transmitted from one generation to another.
Social determinants of health are the social conditions in which people live that determine their health. Illnesses are generally related to social, economic, political, and environmental circumstances. Social determinants of health have been recognized by several health organizations such as the Public Health Agency of Canada and the World Health Organization to greatly influence collective and personal well-being. The World Health Organization's Social Determinants Council also recognizes Social determinants of health in poverty.
When the cause of a disease is poorly understood, societies tend to mythologize the disease or use it as a metaphor or symbol of whatever that culture considers evil. For example, until the bacterial cause of tuberculosis was discovered in 1882, experts variously ascribed the disease to heredity, a sedentary lifestyle, depressed mood, and overindulgence in sex, rich food, or alcohol—all the social ills of the time.
When a disease is caused by a pathogen (e.g., when the disease malaria is caused by infection by Plasmodium parasites.), the term disease may be misleadingly used even in the scientific literature in place of its causal agent, the pathogen. This language habit can cause confusion in the communication of the cause-effect principle in epidemiology, and as such it should be strongly discouraged.
Types of causes
- An airborne disease is any disease that is caused by pathogens and transmitted through the air.
- Foodborne illness or food poisoning is any illness resulting from the consumption of food contaminated with pathogenic bacteria, toxins, viruses, prions or parasites.
- Infectious diseases, also known as transmissible diseases or communicable diseases, comprise clinically evident illness (i.e., characteristic medical signs or symptoms of disease) resulting from the infection, presence and growth of pathogenic biological agents in an individual host organism. Included in this category are contagious diseases – an infection, such as influenza or the common cold, that commonly spreads from one person to another – and communicable diseases – a disease that can spread from one person to another, but does not necessarily spread through everyday contact.
- A lifestyle disease is any disease that appears to increase in frequency as countries become more industrialized and people live longer, especially if the risk factors include behavioral choices like a sedentary lifestyle or a diet high in unhealthful foods such as refined carbohydrates, trans fats, or alcoholic beverages.
- A non-communicable disease is a medical condition or disease that is non-transmissible. Non-communicable diseases cannot be spread directly from one person to another. Heart disease and cancer are examples of non-communicable diseases in humans.
Medical therapies or treatments are efforts to cure or improve a disease or other health problem. In the medical field, therapy is synonymous with the word treatment. Among psychologists, the term may refer specifically to psychotherapy or "talk therapy". Common treatments include medications, surgery, medical devices, and self-care. Treatments may be provided by an organized health care system, or informally, by the patient or family members.
Preventive healthcare is a way to avoid an injury, sickness, or disease in the first place. A treatment or cure is applied after a medical problem has already started. A treatment attempts to improve or remove a problem, but treatments may not produce permanent cures, especially in chronic diseases. Cures are a subset of treatments that reverse diseases completely or end medical problems permanently. Many diseases that cannot be completely cured are still treatable. Pain management (also called pain medicine) is that branch of medicine employing an interdisciplinary approach to the relief of pain and improvement in the quality of life of those living with pain.
Epidemiology is the study of the factors that cause or encourage diseases. Some diseases are more common in certain geographic areas, among people with certain genetic or socioeconomic characteristics, or at different times of the year.
Epidemiology is considered a cornerstone methodology of public health research, and is highly regarded in evidence-based medicine for identifying risk factors for disease. In the study of communicable and non-communicable diseases, the work of epidemiologists ranges from outbreak investigation to study design, data collection and analysis including the development of statistical models to test hypotheses and the documentation of results for submission to peer-reviewed journals. Epidemiologists also study the interaction of diseases in a population, a condition known as a syndemic. Epidemiologists rely on a number of other scientific disciplines such as biology (to better understand disease processes), biostatistics (the current raw information available), Geographic Information Science (to store data and map disease patterns) and social science disciplines (to better understand proximate and distal risk factors). Epidemiology can help identify causes as well as guide prevention efforts.
In studying diseases, epidemiology faces the challenge of defining them. Especially for poorly understood diseases, different groups might use significantly different definitions. Without an agreed-on definition, different researchers may report different numbers of cases and characteristics of the disease.
Some morbidity databases are compiled with data supplied by states and territories health authorities, at national levels or larger scale (such as European Hospital Morbidity Database (HMDB)) which may contain hospital discharge data by detailed diagnosis, age and sex. The European HMDB datea was submitted by European countries to the World Health Organization Regional Office for Europe.
Burdens of disease
Disease burden is the impact of a health problem in an area measured by financial cost, mortality, morbidity, or other indicators.
There are several measures used to quantify the burden imposed by diseases on people. The years of potential life lost (YPLL) is a simple estimate of the number of years that a person's life was shortened due to a disease. For example, if a person dies at the age of 65 from a disease, and would probably have lived until age 80 without that disease, then that disease has caused a loss of 15 years of potential life. YPLL measurements do not account for how disabled a person is before dying, so the measurement treats a person who dies suddenly and a person who died at the same age after decades of illness as equivalent. In 2004, the World Health Organization calculated that 932 million years of potential life were lost to premature death.
The quality-adjusted life year (QALY) and disability-adjusted life year (DALY) metrics are similar, but take into account whether the person was healthy after diagnosis. In addition to the number of years lost due to premature death, these measurements add part of the years lost to being sick. Unlike YPLL, these measurements show the burden imposed on people who are very sick, but who live a normal lifespan. A disease that has high morbidity, but low mortality, has a high DALY and a low YPLL. In 2004, the World Health Organization calculated that 1.5 billion disability-adjusted life years were lost to disease and injury. In the developed world, heart disease and stroke cause the most loss of life, but neuropsychiatric conditions like major depressive disorder cause the most years lost to being sick.
|Disease category||Percent of all YPLLs lost, worldwide||Percent of all DALYs lost, worldwide||Percent of all YPLLs lost, Europe||Percent of all DALYs lost, Europe||Percent of all YPLLs lost, US and Canada||Percent of all DALYs lost, US and Canada|
|Infectious and parasitic diseases, especially lower respiratory tract infections, diarrhea, AIDS, tuberculosis, and malaria||37%||26%||9%||6%||5%||3%|
|Neuropsychiatric conditions, e.g. depression||2%||13%||3%||19%||5%||28%|
|Injuries, especially motor vehicle accidents||14%||12%||18%||13%||18%||10%|
|Cardiovascular diseases, principally heart attacks and stroke||14%||10%||35%||23%||26%||14%|
|Premature birth and other perinatal deaths||11%||8%||4%||2%||3%||2%|
Society and culture
How a society responds to diseases is the subject of medical sociology.
A condition may be considered a disease in some cultures or eras but not in others. For example, obesity can represent wealth and abundance, and is a status symbol in famine-prone areas and some places hard-hit by HIV/AIDS. Epilepsy is considered a sign of spiritual gifts among the Hmong people.
Sickness confers the social legitimization of certain benefits, such as illness benefits, work avoidance, and being looked after by others. The person who is sick takes on a social role called the sick role. A person who responds to a dreaded disease, such as cancer, in a culturally acceptable fashion may be publicly and privately honored with higher social status. In return for these benefits, the sick person is obligated to seek treatment and work to become well once more. As a comparison, consider pregnancy, which is not interpreted as a disease or sickness, even if the mother and baby may both benefit from medical care.
Most religions grant exceptions from religious duties to people who are sick. For example, one whose life would be endangered by fasting on Yom Kippur or during Ramadan is exempted from the requirement, or even forbidden from participating. People who are sick are also exempted from social duties. For example, ill health is the only socially acceptable reason for an American to refuse an invitation to the White House.
The identification of a condition as a disease, rather than as simply a variation of human structure or function, can have significant social or economic implications. The controversial recognitions as diseases of repetitive stress injury (RSI) and post-traumatic stress disorder (also known as "Soldier's heart", "shell shock", and "combat fatigue") has had a number of positive and negative effects on the financial and other responsibilities of governments, corporations and institutions towards individuals, as well as on the individuals themselves. The social implication of viewing aging as a disease could be profound, though this classification is not yet widespread.
Lepers were people who were historically shunned because they had an infectious disease, and the term "leper" still evokes social stigma. Fear of disease can still be a widespread social phenomenon, though not all diseases evoke extreme social stigma.
Social standing and economic status affect health. Diseases of poverty are diseases that are associated with poverty and low social status; diseases of affluence are diseases that are associated with high social and economic status. Which diseases are associated with which states varies according to time, place, and technology. Some diseases, such as diabetes mellitus, may be associated with both poverty (poor food choices) and affluence (long lifespans and sedentary lifestyles), through different mechanisms. The term lifestyle diseases describes diseases associated with longevity and that are more common among older people. For example, cancer is far more common in societies in which most members live until they reach the age of 80 than in societies in which most members die before they reach the age of 50.
Language of disease
An illness narrative is a way of organizing a medical experience into a coherent story that illustrates the sick individual's personal experience.
People use metaphors to make sense of their experiences with disease. The metaphors move disease from an objective thing that exists to an affective experience. The most popular metaphors draw on military concepts: Disease is an enemy that must be feared, fought, battled, and routed. The patient or the healthcare provider is a warrior, rather than a passive victim or bystander. The agents of communicable diseases are invaders; non-communicable diseases constitute internal insurrection or civil war. Because the threat is urgent, perhaps a matter of life and death, unthinkably radical, even oppressive, measures are society's and the patient's moral duty as they courageously mobilize to struggle against destruction. The War on Cancer is an example of this metaphorical use of language. This language is empowering to some patients, but leaves others feeling like they are failures.
Another class of metaphors describes the experience of illness as a journey: The person travels to or from a place of disease, and changes himself, discovers new information, or increases his experience along the way. He may travel "on the road to recovery" or make changes to "get on the right track" or choose "pathways". Some are explicitly immigration-themed: the patient has been exiled from the home territory of health to the land of the ill, changing identity and relationships in the process. This language is more common among British healthcare professionals than the language of physical aggression.
Some metaphors are disease-specific. Slavery is a common metaphor for addictions: The alcoholic is enslaved by drink, and the smoker is captive to nicotine. Some cancer patients treat the loss of their hair from chemotherapy as a metonymy or metaphor for all the losses caused by the disease.
Some diseases are used as metaphors for social ills: "Cancer" is a common description for anything that is endemic and destructive in society, such as poverty, injustice, or racism. AIDS was seen as a divine judgment for moral decadence, and only by purging itself from the "pollution" of the "invader" could society become healthy again. More recently, when AIDS seemed less threatening, this type of emotive language was applied to avian flu and type 2 diabetes mellitus. Authors in the 19th century commonly used tuberculosis as a symbol and a metaphor for transcendence. Victims of the disease were portrayed in literature as having risen above daily life to become ephemeral objects of spiritual or artistic achievement. In the 20th century, after its cause was better understood, the same disease became the emblem of poverty, squalor, and other social problems.
- Cryptogenic disease, a disease whose cause is currently unknown
- Developmental disability, severe, lifelong disabilities attributable to mental or physical impairments
- Environmental disease
- Host-pathogen interaction
- List of incurable diseases
- Mitochondrial disease
- Plant pathology
- Rare disease, a disease that affects very few people
- Sociology of health and illness
- "Disease" at Dorland's Medical Dictionary
- White, Tim (19 December 2014). "What is the Difference Between an 'Injury' and 'Disease' for Commonwealth Injury Claims?". Tindall Gask Bentley. Archived from the original on 27 October 2017. Retrieved 6 November 2017.
- Simandan, Dragos (2018). "Rethinking the health consequences of social class and social mobility". Social Science & Medicine. 200: 258–261. doi:10.1016/j.socscimed.2017.11.037. PMID 29301638.
- "What is the deadliest disease in the world?". WHO. 16 May 2012. Archived from the original on 17 December 2014. Retrieved 7 December 2014.
- Brestoff, Jonathan R.; Artis, David (2015). "Immune Regulation of Metabolic Homeostasis in Health and Disease". Cell. 161 (1): 146–160. doi:10.1016/j.cell.2015.02.022. PMC 4400287. PMID 25815992.
- "Mental Illness—Glossary". US National Institute of Mental Health. Archived from the original on 28 May 2010. Retrieved 18 April 2010.
- "Regents Prep: Living Environment: Homeostasis". Oswego City School District Regents Exam Prep Center. Archived from the original on 25 October 2012. Retrieved 12 November 2012.
- "illness". Dorland's Medical Dictionary for Health Consumers. Elsevier. 2007. Retrieved 6 November 2017 – via medical-dictionary.thefreedictionary.com.
- "sickness" at Dorland's Medical Dictionary
- Emson HE (April 1987). "Health, disease and illness: matters for definition". CMAJ. 136 (8): 811–3. PMC 1492114. PMID 3567788.
- McWhinney IR (April 1987). "Health and disease: problems of definition". CMAJ. 136 (8): 815. PMC 1492121. PMID 3567791.
- Hart BL (1988). "Biological basis of the behavior of sick animals". Neurosci Biobehav Rev. 12 (2): 123–137. doi:10.1016/S0149-7634(88)80004-6. PMID 3050629.
- Johnson R (2002). "The concept of sickness behavior: a brief chronological account of four key discoveries". Veterinary Immunology and Immunopathology. 87 (3–4): 443–450. doi:10.1016/S0165-2427(02)00069-7. PMID 12072271.
- Kelley KW, Bluthe RM, Dantzer R, Zhou JH, Shen WH, Johnson RW, Broussard SR (2003). "Cytokine-induced sickness behavior". Brain Behav Immun. 17 (Suppl 1): S112–118. doi:10.1016/S0889-1591(02)00077-6. PMID 12615196.
- Sefton, Phil. "Condition, Disease, Disorder". AMA Style Insider. American Medical Association. Archived from the original on 21 March 2016. Retrieved 22 July 2016.
- American Psychiatric Association Task Force on DSM-IV (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association. ISBN 978-0-89042-025-6.
- "Expat Insurance Glossary by The Insurance Page". Archived from the original on 27 October 2008. Retrieved 20 November 2008.
- "morbidity". Dorland's Medical Dictionary for Health Consumers. Elsevier. 2007. Retrieved 6 November 2017 – via medical-dictionary.thefreedictionary.com.
- Lenzer, Jeanne (14 August 2012). "Blood pressure drugs for mild hypertension: Not proven to prevent heart attacks, strokes, or early death". Slate. Archived from the original on 15 August 2012. Retrieved 16 August 2012.
- Viera, Anthony J. (2011), "Predisease: when does it make sense?", Epidemiologic Reviews, 33 (1), pp. 122–134, doi:10.1093/epirev/mxr002, PMID 21624963,
When the goal of preventing adverse health outcomes is kept in mind, this review poses the idea that "predisease" as a category on which to act makes sense only if the following 3 conditions are met. First, the people designated as having predisease must be far more likely to develop disease than those not so designated. Second, there must be a feasible intervention that, when targeted to people with predisease, effectively reduces the likelihood of developing disease. Third, the benefits of intervening on predisease must outweigh the harms in the population.
- "clinical disease". Mosby's Medical Dictionary (9th ed.). Elsevier. 2009. Retrieved 6 November 2017 – via medical-dictionary.thefreedictionary.com.
a stage in the history of a pathological condition that begins with anatomical or physiological changes that are sufficient to produce recognizable signs and symptoms of a disease
- "subclinical". Retrieved 6 November 2017 – via medical-dictionary.thefreedictionary.com.
- Loscalzo J1, Kohane I, Barabasi AL. Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol. 2007;3:124. Epub 2007 Jul 10.
- Alexander van Geen, et al. "Impact of population and latrines on fecal contamination of ponds in rural Bangladesh." Science Of The Total Environment 409, no. 17 (August 2011): 3174-3182.
- Olson, James Stuart (2002). Bathsheba's breast: women, cancer & history. Baltimore: The Johns Hopkins University Press. pp. 168–170. ISBN 0-8018-6936-6.
- Marcantonio, Matteo; Pascoe, Emily; Baldacchino, Frederic (January 2017). "Sometimes Scientists Get the Flu. Wrong…!". Trends in Parasitology. 33 (1): 7–9. doi:10.1016/j.pt.2016.10.005.
- Hardy, Paul A.; Hardy, Paul A. J. (1997). Chronic Pain Management: The Essentials. Cambridge University Press. p. 10. ISBN 978-1-900151-85-6. OCLC 36881282. Archived from the original on 3 October 2015.
- Tuller, David (4 March 2011). "Defining an illness is fodder for debate". The New York Times. Archived from the original on 3 January 2017.
- "National Hospital Morbidity Database". aihw.gov.au. Australian Institute of Health and Welfare. Archived from the original on 13 August 2013. Retrieved 11 July 2013.
- "Hospital Morbidity Database (HMDB)". statcan.gc.ca. Statistics Canada. Archived from the original on 30 June 2016. Retrieved 21 September 2015.
- "European Hospital Morbidity Database". who.int. World Health Organization. Archived from the original on 2 September 2013.
- "Disease and injury regional estimates for 2004". who.int. World Health Organization. Archived from the original on 24 December 2010. Standard DALYs (3% discounting, age weights). Also DALY spreadsheet and YLL spreadsheet.
- Gerten-Jackson, Carol. "The Tuscan General Alessandro del Borro". Archived from the original on 2 May 2009.
- Haslam DW, James WP (2005). "Obesity". Lancet. 366 (9492): 1197–209. doi:10.1016/S0140-6736(05)67483-1. PMID 16198769.
- Fadiman, Anne (1997). The spirit catches you and you fall down: a Hmong child, her American doctors, and the collision of two cultures. New York: Farrar, Straus, and Giroux. ISBN 0-374-52564-1.
- Sulik, Gayle (2010). Pink Ribbon Blues: How Breast Cancer Culture Undermines Women's Health. New York: Oxford University Press. ISBN 0-19-974045-3.
- Martin, Judith (2005). Miss Manners' Guide to Excruciatingly Correct Behavior. New York: W.W. Norton & Co. p. 703. ISBN 978-0-393-05874-1. OCLC 57549405.
- Gwyn, Richard (1999). "10". In Cameron, Lynne; Low, Graham. Researching and applying metaphor. Cambridge, England: Cambridge University Press. ISBN 978-0-521-64964-3. OCLC 40881885.
- Span, Paula (22 April 2014). "Fighting Words Are Rarer Among British Doctors". The New York Times. Archived from the original on 2 July 2014.
- Diedrich, Lisa (2007). Treatments: language, politics, and the culture of illness. Minneapolis: University of Minnesota Press. pp. 8, 29. ISBN 978-0-8166-4697-5. OCLC 601862594.
- Hanne M, Hawken SJ (December 2007). "Metaphors for illness in contemporary media". Med Humanit. 33 (2): 93–9. doi:10.1136/jmh.2006.000253. PMID 23674429.
- Health Topics, MedlinePlus descriptions of most diseases, with access to current research articles.
- OMIM Comprehensive information on genes that cause disease at Online Mendelian Inheritance in Man
- CTD The Comparative Toxicogenomics Database is a scientific resource connecting chemicals, genes, and human diseases.
- NLM Comprehensive database from the US National Library of Medicine
- Health Topics A-Z, fact sheets about many common diseases at Centers for Disease Control
- The Merck Manual containing detailed description of most diseases
- Report: The global burden of disease from World Health Organization (WHO), 2004
- Free online health-risk assessment by Your Disease Risk at Washington University in St Louis
- "Man and Disease", BBC Radio 4 discussion with Anne Hardy, David Bradley & Chris Dye (In Our Time, Dec. 15, 2002)