Downtown Oklahoma City is located at the geographic center of the Oklahoma City metropolitan area and contains the principal, central business district of the region. Downtown has over 80,000 workers and over 13,310,000 sq ft (1,237,000 m2) of leasable office space to-date. Downtown Oklahoma City is the legal, financial, economic, nightlife, and entertainment center of the region.

Interstate 40 (I-40) is a major east–west transcontinental Interstate Highway in the southeastern and southwestern portions of the United States. At a length of 2,556.61 miles (4,114.46 km), it is the third-longest Interstate Highway in the country, after I-90 and I-80. From west to east, it passes through California, Arizona, New Mexico, Texas, Oklahoma, Arkansas, Tennessee, and North Carolina. Its western terminus is at I-15 in Barstow, California, while its eastern terminus is at a concurrency with U.S. Route 117 (US 117) and North Carolina Highway 132 (NC 132) in Wilmington, North Carolina. Major cities served by the interstate include Flagstaff, Arizona; Albuquerque, New Mexico; Amarillo, Texas; Oklahoma City, Oklahoma; Little Rock, Arkansas; Memphis, Nashville, and Knoxville in Tennessee; and Asheville, Winston-Salem, Greensboro, Durham, Raleigh, and Wilmington in North Carolina.