Between 2004 and 2018, the United States government attacked thousands of targets in northwest Pakistan using unmanned aerial vehicles (drones) operated by the United States Air Force under the operational control of the Central Intelligence Agency's Special Activities Division. Most of these attacks were on targets in the Federally Administered Tribal Areas along the Afghan border in northwest Pakistan. These strikes began during the administration of United States President George W. Bush, and increased substantially under his successor Barack Obama. Some in the media referred to the attacks as a "drone war". The George W. Bush administration officially denied the extent of its policy; in May 2013, the Obama administration acknowledged for the first time that four US citizens had been killed in the strikes. In December 2013, the National Assembly of Pakistan unanimously approved a resolution against US drone strikes in Pakistan, calling them a violation of "the charter of the United Nations, international laws and humanitarian norms."

Baitullah Mehsud was one of the founders and a leading member of the TTP in Waziristan, Pakistan, and the leader of the Tehrik-e-Taliban Pakistan (TTP). He formed the TTP from an alliance of about five militant groups in December 2007. He is thought by U.S. military analysts to have commanded up to 5,000 fighters and to have been behind numerous attacks in Pakistan including the assassination of Benazir Bhutto which he and others have denied.