Duchesne is a city in and the county seat of Duchesne County, Utah, United States. The population was 1,588 at the 2020 census.

U.S. Route 191 (US-191) is a major 404.168-mile (650.445 km), north–south U.S. Numbered Highway through eastern Utah, United States. The present alignment of US-191, which stretches from Mexico to Canada, was created in 1981 through Utah. Previously the route had entered northern Utah, ending at US-91 in Brigham City, but with the completion of I-15 it was truncated to Yellowstone National Park and re-extended on a completely different alignment. In addition to a large portion of US-163, this extension absorbed several state routes: SR-33, most of SR-44, and SR-260.