Durant is a city near the central eastern border of Holmes County, Mississippi, United States, and Big Black River. The town was founded in 1858 as a station on the Mississippi Central Railroad, later part of the Illinois Central. Durant was named for Louis Durant, a Choctaw chief who had lived on this site before the United States undertook Indian Removal in the 1830s, forcing him and most of the Choctaw to Indian Territory west of the Mississippi River.

Holmes County is a county in the U.S. state of Mississippi; its western border is formed by the Yazoo River and the eastern border by the Big Black River. The western part of the county is within the Yazoo-Mississippi Delta. As of the 2020 census, the population was 17,000. Its county seat is Lexington. The county is named in honor of David Holmes, territorial governor and the first governor of the state of Mississippi and later United States Senator for Mississippi. Holmes County native, Edmond Favor Noel, was an attorney and state politician, elected as governor of Mississippi, serving from 1908 to 1912.