The East Region occupies the southeastern portion of the Republic of Cameroon. It is bordered to the east by the Central African Republic, to the south by Congo, to the north by the Adamawa Region, and to the west by the Centre and South Regions. With 109,002 km2 of territory, it is the largest region in the nation as well as the most sparsely populated. Historically, the peoples of the East have been settled in Cameroonian territory for longer than any other of the country's many ethnic groups, the first inhabitants being the Baka pygmies.

Cameroon, officially the Republic of Cameroon, is a country in Central Africa. It shares boundaries with Nigeria to the west and north, Chad to the northeast, the Central African Republic to the east, and Equatorial Guinea, Gabon and the Republic of the Congo to the south. Its coastline lies on the Bight of Biafra, part of the Gulf of Guinea and the Atlantic Ocean. Due to its strategic position at the crossroads between West Africa and Central Africa, it has been categorized as being in both camps. Its nearly 27 million people speak 250 native languages, in addition to the national tongues of English and French, or both.