Edith Falco is an American actress. She is best known for portraying Carmela Soprano on the HBO series The Sopranos (1999–2007), and Nurse Jackie Peyton on the Showtime series Nurse Jackie (2009–2015). She also portrayed Diane Whittlesey in HBO's prison drama Oz (1997–2000).

The Independent Spirit Award for Best Female Lead was one of the annual Independent Spirit Awards to honor an actress who has delivered an outstanding lead performance in an independent film. It was first presented in 1985 with Geraldine Page being the first recipient of the award for her role as Carrie Watts in The Trip to Bountiful. It was last presented in 2022 with Taylour Paige being the final recipient of the award for her role in Zola.