The Edinburgh Phrenological Society was founded in 1820 by George Combe, an Edinburgh lawyer, with his physician brother Andrew Combe. The Edinburgh Society was the first and foremost phrenology grouping in Great Britain; more than forty phrenological societies followed in other parts of the British Isles. The Society's influence was greatest over its first two decades and declined in the 1840s; the final meeting was recorded in 1870.

George Combe was a Scottish lawyer and a spokesman of the phrenological movement for over 20 years. He founded the Edinburgh Phrenological Society in 1820 and wrote The Constitution of Man (1828). After marriage in 1833, Combe devoted his later years to promoting phrenology internationally.