Edith Wilson was the first lady of the United States from 1915 to 1921 and the second wife of President Woodrow Wilson. She married the widower Wilson in December 1915, during his first term as president. Edith Wilson played an influential role in President Wilson's administration following the severe stroke he suffered in October 1919. For the remainder of her husband's presidency, she managed the office of the president, a role she later described as a "stewardship", and determined which communications and matters of state were important enough to bring to the attention of the bedridden president.

First Lady of the United States (FLOTUS) is the title held by the hostess of the White House, usually the wife of the president of the United States, concurrent with the president's term in office. Although the first lady's role has never been codified or officially defined, she figures prominently in the political and social life of the United States. Since the early 20th century, the first lady has been assisted by official staff, known as the Office of the First Lady and headquartered in the East Wing of the White House.