Edward R. Murrow High School is located in Midwood, Brooklyn, New York, and is operated by the New York City Department of Education. The school is dedicated to the arts, and students can audition for programs in music, fine and visual arts, or theater. The school was established in 1974 by Saul Bruckner, who also served as its first principal, and was named after the renowned broadcast journalist Edward R. Murrow. The school was founded based on the pedagogical theories of John Dewey and the learning and teaching methods of John Dewey High School.

Midwood is a neighborhood in the south-central part of the New York City borough of Brooklyn. It is bounded on the north by the Bay Ridge Branch tracks just above Avenue I and by the Brooklyn College campus of the City University of New York, and on the south by Avenue P and Kings Highway. The eastern border consists of parts of Nostrand Avenue, Flatbush Avenue, and Coney Island Avenue; parts of McDonald Avenue and Ocean Parkway mark the western boundary.