Edward Seymour, 1st Duke of Somerset, 1st Earl of Hertford, 1st Viscount Beauchamp, also known as Edward Semel, was an English nobleman and politician who served as Lord Protector of England from 1547 to 1549 during the minority of his nephew King Edward VI. He was the eldest surviving brother of Queen Jane Seymour, the third wife of King Henry VIII.

John Dudley, 1st Duke of Northumberland was an English general, admiral, and politician, who led the government of the young King Edward VI from 1550 until 1553, and unsuccessfully tried to install Lady Jane Grey on the English throne after the King's death. The son of Edmund Dudley, a minister of Henry VII executed by Henry VIII, John Dudley became the ward of Sir Edward Guildford at the age of seven. Dudley grew up in Guildford's household together with his future wife, Guildford's daughter Jane, with whom he was to have 13 children. Dudley served as Vice-Admiral and Lord Admiral from 1537 until 1547, during which time he set novel standards of navy organisation and was an innovative commander at sea. He also developed a strong interest in overseas exploration. Dudley took part in the 1544 campaigns in Scotland and France and was one of Henry VIII's intimates in the last years of the reign. He was also a leader of the religious reform party at court.