Eleanor Grace Gehrig was an American philanthropist, socialite, and memoirist, known as the wife of American baseball player Lou Gehrig. After Gehrig's death she continued to promote his legacy and contribute to Amyotrophic lateral sclerosis research. In 1976 she released her autobiography, My Luke and I.

Henry Louis Gehrig was an American professional baseball first baseman who played 17 seasons in Major League Baseball (MLB) for the New York Yankees (1923–1939). Gehrig was renowned for his prowess as a hitter and for his durability, which earned him his nickname "the Iron Horse". He is widely regarded as one of the greatest baseball players of all time. He was an All-Star seven consecutive times, a Triple Crown winner once, an American League (AL) Most Valuable Player twice, and a member of six World Series champion teams. He had a career .340 batting average, .632 slugging average, and a .447 on-base average. He hit 493 home runs and had 1,995 runs batted in (RBI). He still has the highest ratio of runs scored plus runs batted in per 100 plate appearances (35.08) and per 100 games (156.7) among Hall of Fame players. In 1939, he was elected to the Baseball Hall of Fame and was the first MLB player to have his uniform number (4) retired by a team.