Anna Eleanor Roosevelt was an American political figure, diplomat, and activist. She was the first lady of the United States from 1933 to 1945, during her husband President Franklin D. Roosevelt's four terms in office, making her the longest-serving first lady of the United States. Through her travels, public engagement, and advocacy, she largely redefined the role of First Lady. Roosevelt then served as a United States Delegate to the United Nations General Assembly from 1945 to 1952, and took a leading role in designing the text and gaining international support for the Universal Declaration of Human Rights. In 1948 she was given a standing ovation by the assembly upon their adoption of the Declaration. President Harry S. Truman later called her the "First Lady of the World" in tribute to her human rights achievements.

First Lady of the United States (FLOTUS) is the title held by the hostess of the White House, usually the wife of the president of the United States, concurrent with the president's term in office. Although the first lady's role has never been codified or officially defined, she figures prominently in the political and social life of the United States. Since the early 20th century, the first lady has been assisted by official staff, known as the Office of the First Lady and headquartered in the East Wing of the White House.