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The Engadin or Engadine is a long high Alpine valley region in the eastern Swiss Alps located in the canton of Graubünden in most southeastern Switzerland with about 25,000 inhabitants. It follows the route of the Inn from its headwaters at Maloja Pass in the southwest running northeast until the Inn flows into Austria, one hundred kilometers downstream; the En/Inn subsequently flows at Passau into the Danube, as the only Swiss river to drain into the Black Sea. The Engadine is protected by high mountain ranges on all sides and is famous for its sunny climate, beautiful landscapes and outdoor activities; the Romansh toponym Engiadina was first attested as Latin vallis Eniatina in AD 930. A derivation from the reconstructed ethnonym *Eniates has been suggested, with the first part of the ethnonym in turn containing the name of the En; the Engadine lies at the most southeastern end of Switzerland and at the western end of the Eastern Alps and constitutes the Swiss part of the 130 kilometres -long valley drained by the En/Inn until it turns northeast again after a large bend to northwest just before Landeck in Austria.

From the Maloja Pass to the border of the Austrian Tyrol just before the Schergenbach, coming from Samnaun, enters the Inn, it runs for the whole Swiss length of 100 kilometres always above 1,000 metres in elevation. The Engadine is connected by the Julier, Albula, Flüela Passes and the Vereina Tunnel to the northern part of Switzerland and the rest of the canton of Grisons, it is reachable from northern Italy by the Maloja Pass to the west and the Bernina Pass to the south. Via the Pass dal Fuorn it connects to the southern Val Müstair and further south over the border to the Val Venosta in Italy; the highest mountains of the wider area of the Engadine is the Bernina Range in the southwestern part. The Engadine is traditionally divided into two parts: The Upper Engadine, from Maloja Pass to the dell near Brail, in the west, where the valley stays flat and is remarkably wide as far as S-chanf, its major center is St. Moritz and bustling during touristic peak seasons and summer; the traditionally spoken Romansh idiom in the Upper Engadine is called Putèr.

The Lower Engadine, from Brail to the Austrian border in the far east, where the Inn drops more runs now more eastwards after Susch, the valley becomes narrower and steeper, the En's path is more tortuous, the area is much more secluded and therefore more quiet. The traditionally spoken Romansh idiom in the Lower Engadine is called Vallader; the Upper Engadine begins at the Maloja mountain pass in the southwest with a subsequent chain of lakes running southwest-northeast: Lej da Segl, Lej da Silvaplauna, both famous for windsurfing, Lej da San Murezzan. To the southwestern side, the Maloja Pass drops precipitously down to the Italian spoken Val Bregaglia and over the Swiss-Italian border further down to Chiavenna, thence southwards to Como. Near the Lunghin Pass, northwest from and above Maloja, lies the most notable triple watershed in Western Europe, from where the water flows via the Inn and via the Danube to the Black Sea, via the Maira and via the Po to the Mediterranean Sea, via the Gelgia and via the Rhine to the North Sea.

The resort of St. Moritz at around 1,800 metres sits on Lej da San Murezzan, it was the host city for the 1948 Winter Olympics. There are numerous ski resorts in the area served by the ski areas of Piz Nair. Northeast of St. Moritz lies the village of Samedan, the capital of the Upper Engadine. Near Samedan, the river Flaz joins the Inn from the south and the valley opens into a wide meadow framed with mountains; the Flaz is a major tributary which flows north, down the Val Bernina starting in Pontresina at the confluence of the Ova da Roseg and Ova da Bernina. Here, on the flat between those two rivers one finds the Engadin Airport; the highest mountain in the wider area of the Engadine – and in the Eastern Alps – is Piz Bernina, 4,049 metres high and 15 kilometres southeast of St. Moritz. Further down from Samedan to the northeast are a number of villages lying on the banks of the Inn. One of it is Zuoz, a village of typical Engadine houses, with large, thick stone and masonry walls, funnel-shaped windows, wall paintings called sgraffito.

These houses are large and are traditionally shared by two or more families, they may have what used to be a stable or livestock area underneath. In a typical Engadine village, there are numerous fountains, free-flowing all year round, which were used for drinking water and for watering livestock; the red trains by Rhaetian Railways connects St. Moritz with Samedan and runs on a north-south axis via the Albula Tunnel to the north and connects the Upper Engadine via Filisur and Thusis with Chur, the capital of the canton and with the rest of Switzerland, to the south via the Bernina Pass (2,253 m (7,3

The Suicide File

The Suicide File was an American hardcore punk band from Boston, Massachusetts that formed in April 2001. The band wrote songs with a political message, although many songs dealt with social and personal problems. Most of the band's output was released on the Southern California-based hardcore label Indecision Records; the band reunited in June 2006 to embark on their first European Tour. Members of the bands are or have been affiliated with The Hope Conspiracy, Death By Stereo, When Tigers Fight, Give Up the Ghost/American Nightmare, Clouds and many more. Most of these are bands with. Dave Weinberg was known for his frequent collaborations and duets with Julie Ecker and James "Boom Boom" Auclair. Despite their short tenure, The Suicide File continues to be revered within the hardcore punk community for their musical output and lasting impression on the flourishing Boston hardcore scene; the band since 2006 has played a small number of sized reunion sets. Dave Weinberg - vocals Neeraj Kane - guitar Jarrod Alexander - drums Jason Correia - guitar John Carpenter - bass Jimmy Carroll - guitar on Things Fall Apart 7" Michael Chung - Guest Producer Twilight - CD/LP Some Mistakes You Never Stop Paying For - CD/LP The Suicide File 7"/CDEP - EP/CDEP The Suicide File / The Hope Conspiracy split 7" - EP The Suicide File / R'N'R split 7" - EP Things Fall Apart 7" - EP Live On WERS 7" - EP "The Suicide File" demo tape The Suicide File on Indecision Records

Mata Hari (1985 film)

Mata Hari is a 1985 erotic biographical film directed by Curtis Harrington, produced by Golan-Globus and featuring Sylvia Kristel in the title role of exotic dancer Mata Hari, executed for espionage during World War I. The film portrays Mata Hari as an innocent woman manipulated by the secret services of Germany and France into providing intelligence, at first unwittingly and unwillingly, driven by the nonpartisan desire to save lives, she is cynically sacrificed by the French who are aware of her innocence but believe her execution will boost morale. The film's convoluted plot is anchored by a fictitious love triangle between Mata Hari and two officers, the French Georges Ladoux and the German Karl von Bayerling. Ladoux and Bayerling are personal friends but end up on opposing sides of the war, providing ample opportunity to explore the dramatic tension between honor and personal loyalty on the one hand and patriotism and duty to one's country on the other, their ethical dilemma is contrasted to the amoral scheming of the main villain, Dr. Elsbeth Schragmüller, a doctor of psychology and leading operative of German intelligence.

Mata Hari's efforts to thwart Fräulein Doktor's assassination plot using a concealed bomb are successful but lead her to be captured in compromising circumstances by Ladoux, precipitating her show trial and execution, which Ladoux fruitlessly tries to prevent. The film ends on a melancholy note with the reconciliation of Bayerling after the war; the film was conceived as a vehicle for Sylvia Kristel. It was announced in January 1984."I wish I had half her energy in the bodouir," said Kristel of Mata Hari. Curtis Harrington called the film an "erotic melodrama; the film never was pornographic. The love scenes are explicit. There is nudity."The director said the movie should have been subtitled The Erotic Adventures With a Spy. "We fictionized events to make the story line work, but it's a true story. Mata Hari used her erotic allure as a woman, she seduced half the men of Europe in her heyday."The film was shot in Budapest, Hungary. Harrington called Kristel "a bright and pleasant lady to work with.

She's this great sex symbol yet that's not where her head is at. Being on the set with her is like going to a Sunday school picnic -- she's so circumspect. During the love scenes, there were black velvet curtains and only three people allowed on the set; some women are so loose and free on the set, they walk around nude. Not Sylvia." Cannon had to cut the film in order to get the film rated R as opposed to X. They did this without Harrington's involvement; the director said he was "disappointed... I wish. There were moments. I'm not happy with the cut, but don't care what I think."Harrington said the censors objected to "elaborately staged love scenes. There was an orgy sequence in Spain with frontal nudity of a living statue grouping. That's all cut out. I would have fought to leave that in because it's harmless, containing nothing of an untoward nature. Few scenes were cut out in their entirety. In minutes I'd guess that seven were cut out." Mata Hari Mata Hari Mata Hari, Agent H21 Fräulein Doktor, a movie about Elsbeth Schragmüller, the Fräulein Doktor of this film Mata Hari on IMDb


Daunorubicin known as daunomycin, is a chemotherapy medication used to treat cancer. It is used for acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, Kaposi's sarcoma, it is used by injection into a vein. A liposomal formulation known as liposomal daunorubicin exists. Common side effects include hair loss, bone marrow suppression, inflammation of the inside of the mouth. Other severe side effects include heart tissue death at the site of injection. Use in pregnancy may harm the baby. Daunorubicin is in the anthracycline family of medication, it works in part by blocking the function of topoisomerase II. Daunorubicin was approved for medical use in the United States in 1979, it is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. The wholesale cost in the developing world is about 5.79 to 37.18 USD for a 20 mg vial. This amount in the United Kingdom costs the NHS about 55.00 pounds. It was isolated from bacteria of the Streptomyces type.

It stops the growth of cancer cells in the body. Treatment is performed together with other chemotherapy drugs, its administration depends on the type of tumor and the degree of response. In addition to its major use in treating AML, daunorubicin is used to treat neuroblastoma. Daunorubicin has been used with other chemotherapy agents to treat the blastic phase of chronic myelogenous leukemia. Daunorubicin is used as the starting material for semi-synthetic manufacturing of doxorubicin and idarubicin. Similar to doxorubicin, daunorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis; this inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove.

It has the highest preference for two adjacent G/C base pairs flanked on the 5' side by an A/T base pair. Crystallography shows that daunomycin induces a local unwinding angle of 8°, other conformational disturbances of adjacent and second-neighbour base pairs, it can induce histone eviction from chromatin upon intercalation. In the 1950s, an Italian research company, Farmitalia Research Laboratories, began an organized effort to isolate anticancer compounds from soil-based microbes. A soil sample was isolated from the area surrounding the Castel del Monte, a 13th-century castle in Apulia. A new strain of Streptomyces peucetius which produced a red pigment was isolated, an antibiotic was produced from this bacterium, found to have good activity against murine tumors. Since a group of French researchers discovered the same compound at about the same time, the two teams named the compound daunorubicin, combining the name Dauni, a pre-Roman tribe that occupied the area of Italy where the compound was isolated, with the French word for ruby, describing the color.

Clinical trials began in the 1960s, the drug saw success in treating acute leukemia and lymphoma. However, by 1967, it was recognized. In 2015-16, a team at Ohio State University "showed that, by manipulating strands of viral DNA, an origami structure with complex folds can be created in just 10 minutes; these structures are only 100 nanometers across – that’s 1,000 times smaller than the width of a human hair. Small volumes of daunorubicin can be wrapped up in these minuscule pods, which can be released into a leukemia cell-filled environment." Daunorubicin should only be administered in a rapid intravenous infusion. It should not be administered intramuscularly or subcutaneously, since it may cause extensive tissue necrosis, it should never be administered intrathecally, as this will cause extensive damage to the nervous system and may lead to death. Daunorubicin has been used intravitreally for the purposes of preventing proliferative vitreoretinopathy, a common complication following retinal detachment surgery, but has not been found to be effective and is not used for any other ophthalmic purposes at this time.

Doxorubicin Idarubicin Information from Macmillan Cancer Support Mediline Plus – Drug Info

Johannes Pieterse van Brugh

Johannes Pieterse van Brugh was one of the early settlers of New Netherland and is the progenitor of the Van Brugh family in the United States. He was prominently connected with the Dutch West India Company as a fur and timber trader in both Rensselaerswyck and New Amsterdam. Johannes Pieterse van Brugh was born in Haarlem, The Netherlands in 1624. After emigrating to New Amsterdam, Van Brugh became a prominent trader with the Dutch West India Company and was one of the burgomasters of the city in 1656, he prospered in New Netherland by timber consigned from upriver at Beverwijck. Due to his wealth, Van Brugh became a civic leader and improved his status in the new world by marrying his four daughters and two sons to some of the leading landholding families of the time, his estate was located on property between Wall and William Streets on the west side of Pearl Street in what is today the Financial District of Manhattan. On March 29, 1658, Van Brugh was married at New Amsterdam Dutch Reformed Church to Catharine Roeloffe Jans, widow of Lucas Rodenburgh, late vice-director of Curaçao.

She was the daughter of Anneke Jans. Together, they were the parents of several children together including: Helena Van Brugh, who married Theunis De Kay, who owned land on Whitehall Street. Anna Van Brugh, who married Andries Grevenraet. Catharina Van Brugh, who married Hendrick van Rensselaer, director of the Eastern patent and son of Jeremias van Rensselaer, the acting Patroon of the Manor of Rensselaerswyck. Pieter Van Brugh, who served as Mayor of Albany, New York from 1699 to 1700 and again from 1721 to 1723, he married Sara Cuyler. Maria Van Brugh, who married Stephen Richard, the grandson of a French nobleman. Johannes Van Brugh II, who married Margaretta Provoost, sister of David Provoost, the 24th Mayor of New York City. Van Brugh made his will on December 22, 1696 and died in 1697. Through his daughter Anna, he was an ancestor of J. Hooker Hamersley, the prominent Gilded Age lawyer and poet. Through his daughter Catharina, he was the grandfather of: Maria Van Rensselaer, who married Samuel Ten Broeck, son of Dirck Wesselse Ten Broeck.

Through his son Pieter, he was the grandfather of Catharina Van Brugh, who married Philip Livingston, the second lord of Livingston Manor. Notes SourcesHowell, George Rogers Bi-centennial History of Albany: History of the County of Albany, N. Y. from 1609 to 1886 Venema, Janny Beverwijck: A Dutch Village on the American Frontier, 1652-1664 ISBN 978-0791460801 Loucks-Wallace Genealogy

And the Weathermen Shrug Their Shoulders

And the Weathermen Shrug Their Shoulders is the second of two albums by Dutch punk band The Ex in collaboration with avant-garde cellist Tom Cora. Dean McFarlane of Allmusic writes that the "second album of this winning collaboration continue to indulge collective love for European folk themes and free improvisation." He praised "the delicate melodious folk, curious improvised sound-searching" which "marked a new tangent the group followed into a total free-form improvisation inspired by the likes of avant-garde jazz associates Han Bennink and Misha Mengelberg." Despite this, he writes that the group " never left their punk roots behind" and concluded by calling them "one of the genre's most interesting and inventive groups." Trouser Press wrote that while the album was inferior to its predecessor, this "denser, darker album has its share of great songs "Dere Geliyor Dere" and two excuses for singer G. W. Sok to run off at the mouth and sound good doing it: "What's the Story" and the hilarious fake materialist manifesto, "Everything & Me.""

The track "War O. D." was praised as "one of the sharpest songs they've written and musically." Bill Meyer wrote for Chicago Reader that both the collaborative albums "reveal an intoxicating chemistry. The Ex push Cora to play more directly than usual, while his improvisational chops and broad musical vocabulary have facilitated the live realization of the promise shown on Joggers and Smoggers his delicately plucked accents articulate the Oriental flavor of "Okinawa Mon Amour." He may be only one player, but he has an unusually broad and exotic musical vocabulary, with his assistance the Ex can now improvise and interpret European and Asian folk songs onstage." "Dere Geliyor Dere" - 4:20 "The Big Black" - 5:33 "What's the Story" - 2:19 "Lamp Lady" - 3:48 "One-Liner from China" - 1:32 "Everything and Me" - 3:59 "New Clear Daze" - 4:41 "Oh Puckerlips Now" - 4:04 "Empty V" - 2:25 "Okinawa Mon Amour" - 2:26 "Dear House" - 4:41 "Conviction Going Gaga" - 1:36 "Stupid Competitions" - 4:15 "Hickwall" - 3:11 "War OD" - 6:12 "Untitled" - 2:01 Terrie G.

W. Sok Luc Andy Katrin Tom Cora. Recorded at Friends Studio, Netherlands. Produced by Dolf Planteijdt. Cogan, Brian. Encyclopedia of Punk Music and Culture. Westport, Conn.: Greenwood Press, 2006. P. 70. ISBN 978-0-313-33340-8. Mount, Heather. "Three Looks into The Ex". In Crane, Larry. Tape Op: The Book about Creative Music Recording, Volume 2. Milwaukee: Hal Leonard Corporation, 2010. Pp. 230–233. Robbins, Ira A. ed. The Trouser Press Guide to'90s Rock: The all-new 5th edition of The Trouser Press Record Guide. New York: Simon & Schuster, 1997. ISBN 0684814374. Sok, G. W. A Mix of Bricks & Valentines: Lyrics 1979–2009. New York: PM Press, 2011. Temporary Services. Group Work. New York: Printed Matter, March 2007