Tsarina Eudoxia Fyodorovna Lopukhina was the first wife of Peter I the Great, and the last ethnic Russian and non-foreign wife of a Russian monarch. She was the mother of Tsarevich Alexei Petrovich and the paternal grandmother of Peter II of Russia.

Tsarina or tsaritsa is the title of a female autocratic ruler (monarch) of Bulgaria, Serbia or Russia, or the title of a tsar's wife. The English spelling is derived from the German czarin or zarin, in the same way as the French tsarine / czarine, and the Spanish and Italian czarina / zarina. (A tsar's daughter is a tsarevna.)