Expedition 53 was the 53rd expedition to the International Space Station, which began upon the departure of Soyuz MS-04 on September 2, 2017, and concluded upon the departure of Soyuz MS-05 on December 14, 2017. Randolph Bresnik, Paolo Nespoli and Sergey Ryazansky were transferred from Expedition 52, with Randolph Bresnik taking the commander role. Transfer of Command from Expedition 53 to Expedition 54 was done on December 13, 2017. Expedition 53 officially ended on December 14, 2017 5:14 UTC, with the undocking of Soyuz MS-05.

The International Space Station (ISS) is a large space station assembled and maintained in low Earth orbit by a collaboration of five space agencies and their contractors: NASA, Roscosmos (Russia), JAXA (Japan), ESA (Europe), and CSA (Canada). The ISS is the largest space station ever built. Its primary purpose is to perform microgravity and space environment experiments.