Exsurge Domine is a papal bull promulgated on 15 June 1520 by Pope Leo X. It was written in response to the teachings of Martin Luther which opposed the views of the Catholic Church. The bull censured forty-one propositions abstracted from Luther's writings, and threatened him with excommunication unless he recanted within a sixty-day period commencing upon the publication of the bull in Saxony and its neighboring regions.

A papal bull is a type of public decree, letters patent, or charter issued by a pope of the Catholic Church. It is named after the leaden seal (bulla) traditionally appended to authenticate it.