The E.464 is a class of Italian railways electric locomotives. They were introduced in the course of the 1990s for hauling light trains, especially for commuter service. They were acquired by FS Trenitalia to replace the old E.424 and E.646, dating from the 1940s and 1950s. The class was originally designed by ABB Trazione, later ADTranz, and produced in the Italian plant of Vado Ligure.

Trenitalia is the primary train operator in Italy. A subsidiary of Ferrovie dello Stato Italiane, itself partly owned by the Italian government, the company and partly from a private investors group. It was established in 2000 following a European Union directive on the deregulation of rail transport.