Fail-Safe is a bestselling American novel by Eugene Burdick and Harvey Wheeler. Expanded from Wheeler's short story "Abraham '59", it was initially serialized in three installments in the Saturday Evening Post on October 13, 20, and 27, 1962, during the Cuban Missile Crisis.

Nuclear warfare, also known as atomic warfare, is a military conflict or prepared political strategy that deploys nuclear weaponry. Nuclear weapons are weapons of mass destruction; in contrast to conventional warfare, nuclear warfare can produce destruction in a much shorter time and can have a long-lasting radiological result. A major nuclear exchange would likely have long-term effects, primarily from the fallout released, and could also lead to secondary effects, such as "nuclear winter", nuclear famine, and societal collapse. A global thermonuclear war with Cold War-era stockpiles, or even with the current smaller stockpiles, may lead to various scenarios including the extinction of the human species.