Filamentous bacteriophage
Filamentous bacteriophages are a family of viruses (Inoviridae) that infect bacteria, or bacteriophages. They are named for their filamentous shape, a worm-like chain, about 6 nm in diameter and about 1000-2000 nm long. This distinctive shape reflects their method of replication: the coat of the virion comprises five types of viral protein, which are located in the inner membrane of the host bacterium during phage assembly, and these proteins are added to the nascent virion's DNA as it is extruded through the membrane. The simplicity of filamentous phages makes them an appealing model organism for research in molecular biology, and they have also shown promise as tools in nanotechnology and immunology.
Filamentous phage virion--schematic views
Assembled major coat protein subunits in Ff (fd, f1, M13) filamentous bacteriophage (genus Inovirus), exploded view.
A bacteriophage, also known informally as a phage, is a virus that infects and replicates within bacteria and archaea. The term was derived from "bacteria" and the Greek φαγεῖν, meaning "to devour". Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have structures that are either simple or elaborate. Their genomes may encode as few as four genes and as many as hundreds of genes. Phages replicate within the bacterium following the injection of their genome into its cytoplasm.
Bacteriophage T2, a member of the Myoviridae due to its contractile tail
Félix d'Herelle conducted the first clinical application of a bacteriophage
George Eliava pioneered the use of phages in treating bacterial infections
In this electron micrograph of bacteriophages attached to a bacterial cell, the viruses are the size and shape of coliphage T1