Flight controllers are personnel who aid space flight by working in such Mission Control Centers as NASA's Mission Control Center or ESA's European Space Operations Centre. Flight controllers work at computer consoles and use telemetry to monitor various technical aspects of a space mission in real-time. Each controller is an expert in a specific area and constantly communicates with additional experts in the "back room". The flight director, who leads the flight controllers, monitors the activities of a team of flight controllers, and has overall responsibility for success and safety.

A mission control center is a facility that manages space flights, usually from the point of launch until landing or the end of the mission. It is part of the ground segment of spacecraft operations. A staff of flight controllers and other support personnel monitor all aspects of the mission using telemetry, and send commands to the vehicle using ground stations. Personnel supporting the mission from an MCC can include representatives of the attitude control system, power, propulsion, thermal, attitude dynamics, orbital operations and other subsystem disciplines. The training for these missions usually falls under the responsibility of the flight controllers, typically including extensive rehearsals in the MCC.