The Flint and Pere Marquette Railroad (F&PM) is a defunct railroad which operated in the U.S. state of Michigan between 1857 and 1899. It was one of the three companies which merged to become the Pere Marquette Railway.

The Pere Marquette Railway was a railroad that operated in the Great Lakes region of the United States and southern parts of Ontario in Canada. It had trackage in the states of Michigan, Ohio, Indiana, and the Canadian province of Ontario. Its primary connections included Buffalo; Toledo; and Chicago. The company was named after Jacques Marquette, a French Jesuit missionary who founded Michigan's first European settlement, Sault Ste Marie.