Cuba's foreign policy has been fluid throughout history depending on world events and other variables, including relations with the United States. Without massive Soviet subsidies and its primary trading partner, Cuba became increasingly isolated in the late 1980s and early 1990s after the fall of the USSR and the end of the Cold War, but Cuba opened up more with the rest of the world again starting in the late 1990s when they have since entered bilateral co-operation with several South American countries, most notably Venezuela and Bolivia beginning in the late 1990s, especially after the Venezuela election of Hugo Chávez in 1999, who became a staunch ally of Castro's Cuba. The United States used to stick to a policy of isolating Cuba until December 2014, when Barack Obama announced a new policy of diplomatic and economic engagement. The European Union accuses Cuba of "continuing flagrant violation of human rights and fundamental freedoms". Cuba has developed a growing relationship with the People's Republic of China and Russia. Cuba provided civilian assistance workers – principally medical – to more than 20 countries. More than one million exiles have escaped to foreign countries. Cuba's present foreign minister is Bruno Rodríguez Parrilla.

The Cuban Revolution was a military and political effort to overthrow the government of Cuba between 1953 and 1959. It began after the 1952 Cuban coup d'état which placed Fulgencio Batista as head of state. After failing to contest Batista in court, Fidel Castro organized an armed attack on the Cuban military's Moncada Barracks on July 26, 1953. The rebels were arrested and while in prison formed the 26th of July Movement (M-26-7). After gaining amnesty the M-26-7 rebels organized an expedition from Mexico on the Granma yacht to invade Cuba. In the following years the M-26-7 rebel army would slowly defeat the Cuban army in the countryside, while its urban wing would engage in sabotage and rebel army recruitment. Over time the originally critical and ambivalent Popular Socialist Party would come to support the 26th of July Movement in late 1958. By the time the rebels were to oust Batista the revolution was being driven by the Popular Socialist Party, 26th of July Movement, and the Revolutionary Directorate of March 13.