The foreign relations of Imperial China from the Qin dynasty until the Qing dynasty encompassed many situations as the fortunes of dynasties rose and fell. Chinese culture had influenced neighboring and distant countries, while being transformed by outside influences as well as being conquered. During the Western Han dynasty, the Silk Road trade routes were established and brought Hellenistic Central Asia, Persia under the Parthian Empire, and South Asia into contact with the Chinese empire. During the 2nd century BC, Zhang Qian became the first known Chinese diplomat to venture deep into Central Asia in search of allies against the Mongolic Xiongnu confederation. Han Chinese attempts were made at reaching the Roman Empire and although the mission led by Gan Ying in 97 AD was a failure, Chinese historical records nevertheless maintain that the Romans traveled to southern China and Vietnam via the Indian Ocean. Buddhism from India was introduced to China during the Eastern Han period and would spread to neighboring Vietnam, Korea, and Japan, all of which would adopt similar Confucian cultures based on the Chinese model.

The Parthian Empire, also known as the Arsacid Empire, was a major Iranian political and cultural power centered in ancient Iran from 247 BC to 224 AD. Its latter name comes from its founder, Arsaces I, who led the Parni tribe in conquering the region of Parthia in Iran's northeast, then a satrapy (province) under Andragoras, who was rebelling against the Seleucid Empire. Mithridates I greatly expanded the empire by seizing Media and Mesopotamia from the Seleucids. At its height, the Parthian Empire stretched from the northern reaches of the Euphrates, in what is now central-eastern Turkey, to present-day Afghanistan and western Pakistan. The empire, located on the Silk Road trade route between the Roman Empire in the Mediterranean Basin and the Han dynasty of China, became a center of trade and commerce.