Fort Myers is a city in and the county seat of Lee County, Florida, United States. The Census Bureau's Population Estimates Program calculated that the city's population was 95,949 in 2022, ranking the city the 370th-most-populous in the country. Together with the larger and more residential city of Cape Coral, the smaller cities of Fort Myers Beach, Sanibel, and Bonita Springs, the village of Estero, and the unincorporated districts of Lehigh Acres and North Fort Myers, it anchors the Cape Coral-Fort Myers, FL metropolitan statistical area (MSA) which comprises Lee County and has a population of 834,573 as of 2023.

Lee County is located in southwestern Florida, United States, on the Gulf Coast. As of the 2020 census, its population was 760,822. In 2022, the population was 822,453, making it the eighth-most populous county in the state. The county seat is Fort Myers, with a population of 86,395 as of the 2020 census, and the largest city is Cape Coral, with an estimated 2020 population of 194,016.