Lee County is located in southwest Florida on the Gulf Coast. As of the 2010 census, the population was 618,754; the county seat is Fort Myers, the largest city is Cape Coral with an estimated 2018 population of 189,343. Lee County comprises the Cape Coral -- FL Metropolitan Statistical Area. Lee County was created in 1887 from Monroe County. Today, Fort Myers is the center of a popular tourist area in Southwest Florida and the seat of Lee County, it is about 120 miles south of Tampa at the meeting point of the Gulf of Mexico and the Caloosahatchee River. Lee County is the spring home of the Boston Red Sox and Minnesota Twins MLB teams for spring training. After Florida became a U. S. territory in 1821, a number of settlers moved into Florida, causing conflict with the local Seminole Indians. Fort Myers was built in 1850 as a military fort to fend off Seminole Indians during the Seminole Wars; the fort was named after Col. Abraham C. Myers, stationed in Florida for seven years and was the son-in-law of the fort's establisher and commander.
In 1858, after years of elusive battle, Chief Billy Bowlegs and his warriors were persuaded to surrender and move west, the fort was abandoned. Billy's Creek, which flows into the Caloosahatchee River, was named after a temporary camp where Billy Bowlegs and his men awaited ships to take them west. In 1863, the fort was reoccupied by federal troops during the Civil War. In 1865, in the Battle of Fort Myers, the fort was attacked by a small group of Confederates; the Union's garrison, led by Captain James Doyle held the fort and the Confederate forces retreated. After the war, the fort was again deserted; the fort was disassembled and some of its wood was contributed towards the building of parts of downtown Fort Myers. The first settlers in Fort Myers arrived in 1866. In the 1870s, Tervio Padilla, a wealthy merchant from the Canary Islands, came by way of Key West to Cayo Costa and established trade with natives and "ranchos" that extended northward to Charlotte Harbor, his ships made port at Cayo Costa at the entrance to the harbor.
Enchanted by the tropical island, he decided to settle there. Padilla prospered until the outbreak of the Spanish–American War, when his fleet was burned and scuttled, he turned to another means of livelihood – fishing. When the government claimed his land, he was disinclined to set up another ranch, so moved with his wife further down the island and as before homesteaded; the Padilla family is one of the first pioneer families of Lee County and many still reside within the county around the Pine Island area. In 1882, the city experienced a significant influx of settlers. By 1885, when Fort Myers was incorporated, its population of 349 residents made it the second-largest city only to Tampa on Florida's west coast south of Cedar Key larger than Clearwater and Sarasota growing cities at the time; the city of Fort Myers was incorporated in 1886. Lee County was created in 1887 from Monroe County, it was named for Confederate general in the American Civil War. Fort Myers first became a nationally known winter resort with the opening of the Royal Palm Hotel in 1898, built by New York City department store magnate Hugh O'Neill.
Fort Myers was the frequent winter home of Thomas Edison, as well as Henry Ford. Construction of the Tamiami Trail Bridge, built across the Caloosahatchee River in 1924, sparked the city's growth. After the bridge's construction, the city experienced its first real estate boom and many subdivisions sprouted around the city. In 1923, Collier and Hendry Counties were created by splitting these areas from Lee County. Following the end of World War II, the Royal Palm Hotel was closed permanently, in 1947, the hotel on the corner of First and Fowler was torn down. Lee County has been the host to several Major League Baseball teams for spring training over the past several decades; the county received a boost in 1983. According to the U. S. Census Bureau, the county has a total area of 1,212 square miles, of which 785 square miles is land and 428 square miles is water. Rivers and streams include the Caloosahatchee River, the Imperial River, the Estero River, Hendry Creek, Orange River. Lee County is on the southwest coast of Florida.
It is about 125 miles south of Tampa and 115 miles west of Fort Lauderdale via Interstate 75. S. Highway 41. Charlotte County Glades County Collier County Hendry County Caloosahatchee National Wildlife Refuge J. N. "Ding" Darling National Wildlife Refuge Matlacha Pass National Wildlife Refuge Pine Island National Wildlife Refuge Lee County has a year-round warm, monsoon-influenced climate, close to the boundary between tropical and subtropical climates, thus is either classified as a humid subtropical climate, the classification used by NOAA, or a tropical savanna climate. Lee County has short, warm winters, long, humid summers, with most of the year's rainfall occurring from June to September; the temperature rises to 100 °F or lowers to the freezing mark. At 89, Lee County leads the nation in the number of days annually in which a thunderstorm is close enough for thunder to be heard; the monthly daily average temperature ranges from 64.2 °F in January to 83.4 °F in August, with the annual mean being 75.1 °F. Records range from 24 °F on December 29, 1894 up to 103 °F on June 16–17, 1981.
On August 1
Iniparib was a drug candidate for cancer treatment. It was believed to act as an irreversible inhibitor of PARP1 and other enzymes through covalent modification, but its effects against PARP were disproven, it underwent clinical trials for treatment of some types of breast cancer, but was discontinued after disappointing phase III clinical trials. Iniparib was the first putative PARP inhibitor to commence phase III clinical trials; the first was for breast cancer, another was for squamous-cell lung cancer. Preliminary results in June 2009 on triple-negative breast cancer were promising. Results showed increased median survival of triple-negative breast cancer patients from 7.7 to 12.2 months. In 2009, the FDA began fast-tracking the new drug application of iniparib for triple-negative breast cancer. However, phase III results disclosed in January 2011 were disappointing. Iniparib was studied as a potential chemotherapeutic agent in the fight against malignant glioma, including glioblastoma. Glioma is a resilient type of primary brain tumor that has limited effective therapies for patients whose tumors are in an inoperable location of the brain, such as the interior of the brainstem.
During the 2013 American Society of Clinical Oncology conference, Sanofi disclosed that iniparib failed to help lung-cancer patients in a late-stage trial, prompting the company to end research into the once-promising compound and take a $285 million charge
Margit Angerer was a Hungarian opera soprano. Margit Rupp was born in Budapest, she studied at the Fodor Conservatorium and at the Budapest Music Academy where she was taught by Arturo de Sanctis. She made her debut in Budapest. After her marriage to logistics entrepreneur Gottfried Schenker-Angerer in 1919 she joined her husband in Vienna, where their daughter Maria was born in 1922. Angerer made herself a reputation in the Lieder genre through performances in Vienna. In 1928 she gave the world premier of "Three sings for singer and piano Opus 22" by Korngold, accompanied by the composer himself as pianist, she made her Vienna opera debut in 1926 as Leonora in Verdi's La forza del destino. Marcel Prawy wrote of her debut: Margit Schenker-Angerer, a prominent figure of Viennese society, was extremely good-looking, with the smile and the figure of a Botticelli nymph... Her friends and acquaintances were just waiting for the merchant's wife to come a cropper and disgrace the entire opera as well as herself.
Was it not a clear case of a stage-struck amateur aspiring to make a career as a singer with her husband's money and position behind her? But as the premiere took its course it became obvious that'Manzi' was a professional to her finger-tips, as Leonora she went from strength to strength, while the face of the friends and acquaintances grew redder and redder"In 1927 she signed a contract with the Vienna State Opera, where she appeared more than 160 times in solo roles until 1935. Abroad, she used the stage names Margit Schenker-Angerer. Angerer worked outside of Vienna, notably at the Salzburg Festival where she appeared in 1930, 1933 and 1935 as Octavian in Der Rosenkavalier, she played Octavian in Vienna, too: it appears to have been the role for which she was best known. In May 1929 Hugo von Hofmannsthal wrote to Richard Strauss: "Angerer's Octavian is charming and better. Other frequent stage portrayals included Elsa in Lohengrin and Dorota in Weinberger's Schwanda the Bagpiper. In Salzburg, she made her first appearance during the 1930 Festspiele in the title role in Gluck's Iphigénie en Aulide.
Three years she appeared there as Aithra in Die ägyptische Helena, a less well known product of the long professional partnership between Richard Strauss and his librettist Hugo von Hofmannsthal. Her role as "the concert singer" in Gustav Fröhlich's Rakoczy-Marsch is her only known appearance in film. Angerer stopped working at the Vienna State Opera in 1935, although sources indicate that she continued to appear as a Lieder singer. There are indications that her retirement from the opera house may have resulted from her having been identified as a political dissident, critical of the authoritarian regime that had come to power in 1934. In November 1946, she applied for and was given membership in the Association of Political Prisoners. In her application she stated that in October 1944, while still living in Vienna and her daughter had been imprisoned by the Gestapo, it does. In 1949 she married Stephan Karpeles-Schenker at Westminster in England, her various recordings were issued as individual 78rpm discs and collected on a 33rpm black disc album and as a CD.
She made recordings with Alfred Piccaver between 1928 and 1930
Harshavarman III was a king of Khmer who ruled from 1066 to about 1080 AD. He succeeded his elder brother Udayadityavarman II and his capital was the so-called Second Yasodharapura, which had its center in Baphuon, built by his brother, West Baray as its principal bàrày, his reign was upset by internal rebellions that he was not able to battle out. So Harshavarman III was the last ruler of his dynasty, his successor, Jayavarman VI, was an usurper who came from Phimai area, on the Khorat Plateau, in present-day Thailand. Harshavarman received the posthumous name of Sadaśivapada, he was named in stele K.908 at Preah Khan as a maternal ancestor of Jayavarman VII if a long dispute rose out of this issue. Between 1074 and 1080, the kingdom had to undergo the invasion by the Champa Prince Pang, a younger brother of the Champa king Harivarman IV, himself the future king Paramabodhisattva. Sambhupra temples were destroyed and the inhabitants were taken into slavery to My Son, including the prince Sri Nandavarmadeva.
In 1076, Champa, was driven by the Chinese Empire in an attack against the Tonkin. The defeat of the Chinese army Đại Việt brought before the retirement of its allies. Higham, Charles; the Civilization of Angkor. Phoenix. ISBN 1-84212-584-2
Starport: Galactic Empires is a free, space-oriented, massively multiplayer online role-playing game by American studio Playtechtonics which uses a third-person overhead view similar to that used in Asteroids. The game uses realistic 2-dimensional physics for both space and atmospheric travel, affecting both the movement of ships and player-fired weaponry. Characters can conquer and colonize planets with a variety of different terrains depending on the type of planet; the player can harvest resources, generate money, produce weapons with their colony. Starport shares many core concepts with Tradewars 2002, notably the commodity trading and planet controlling aspects. Starport is notable in the MMORPG genre as being one of the earliest adopters of the free to play business model. Instead of charging players a monthly subscription fee, Starport is instead free to play and allows players to purchase extra resources in the game through a feature called "The Admiral's Club." Players are given a spaceship to travel through galaxies to either trade, pvp or create colonies for income.
Players are able to take over other people's colonies by settling into another person's HQ base. Commodities play a large role in the universal economy, with different means of obtaining them either through trade, colonies or pvp. Official Starport: Galactic Empires Website "Starport: Galactic Empires Interview". Rpgvault.ign.com. Retrieved 2007-07-26
The Australian Institute of Petroleum is a representative body for Australia's petroleum industry. Its headquarters a located in Canberra and it was established in 1976; the body is managed by a board composed of chief executives, senior representatives and an Executive Director. The organisation aims to support the development of sustainable, internationally competitive petroleum products industry; the four core members include BP Australia, Caltex Australia, Mobil Australia and Shell Company of Australia. Its members operate all oil refineries in Australia; the AIP owns the Australian Marine Oil Spill Centre. It is a member of the Australian Industry Greenhouse Network; the AIP produces a weekly fuel report detailing average prices for transport fuels by location. Energy in Australia Road transport in Australia Official website